Gene description for MLC1
Gene name
megalencephalic leukoencephalopathy with subcortical cysts 1
Gene symbol
MLC1
Other names/aliases
LVM MLC VL
Species
Homo sapiens
Database cross references - MLC1
ExoCarta
ExoCarta_23209
Vesiclepedia
VP_23209
Entrez Gene
23209
HGNC
17082
MIM
605908
UniProt
Q15049
MLC1 identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Gene ontology annotations for MLC1
Experiment description of studies that identified MLC1 in exosomes
1
Experiment ID
231
MISEV standards
✘
Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
MISEV standards
✘
Biophysical techniques
✘
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for MLC1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
LETM1
3954
Affinity Capture-MS
Homo sapiens
2
PTGES2
80142
Affinity Capture-MS
Homo sapiens
3
MDC1
Affinity Capture-MS
Homo sapiens
4
MZT2B
80097
Affinity Capture-MS
Homo sapiens
5
NOMO1
23420
Affinity Capture-MS
Homo sapiens
6
KDM1A
23028
Two-hybrid
Homo sapiens
7
PRMT6
Two-hybrid
Homo sapiens
8
VAMP3
9341
Affinity Capture-MS
Homo sapiens
9
FGFR1
2260
Affinity Capture-MS
Homo sapiens
10
MYLK
4638
Biochemical Activity
Homo sapiens
11
YTHDF1
54915
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which MLC1 is involved
No pathways found