Gene description for FUZ
Gene name fuzzy planar cell polarity protein
Gene symbol FUZ
Other names/aliases FY
NTD
Species Homo sapiens
 Database cross references - FUZ
ExoCarta ExoCarta_80199
Entrez Gene 80199
HGNC 26219
MIM 610622
UniProt Q9BT04  
 FUZ identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FUZ
Biological Process
    regulation of smoothened signaling pathway GO:0008589 ISS
    positive regulation of cilium assembly GO:0045724 IMP
    establishment of planar polarity GO:0001736 ISS
    negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation GO:2000314 ISS
    embryonic skeletal system morphogenesis GO:0048704 ISS
    nonmotile primary cilium assembly GO:0035058 IMP
    cilium assembly GO:0042384 ISS
    negative regulation of cell migration GO:0030336 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    neural tube closure GO:0001843 ISS
    protein transport GO:0015031 IEA
    hair follicle development GO:0001942 ISS
    negative regulation of cell proliferation GO:0008285 ISS
    spinal cord dorsal/ventral patterning GO:0021513 IEA
    embryonic body morphogenesis GO:0010172 ISS
    negative regulation of neural crest formation GO:0090301 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified FUZ in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FUZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGC10731  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FUZ is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome





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