Gene description for FUZ
Gene name fuzzy planar cell polarity protein
Gene symbol FUZ
Other names/aliases FY
NTD
Species Homo sapiens
 Database cross references - FUZ
ExoCarta ExoCarta_80199
Vesiclepedia VP_80199
Entrez Gene 80199
HGNC 26219
MIM 610622
UniProt Q9BT04  
 FUZ identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FUZ
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 ISS
Biological Process
    establishment of planar polarity GO:0001736 ISS
    establishment of planar polarity GO:0001736 NAS
    neural tube closure GO:0001843 IMP
    neural tube closure GO:0001843 ISS
    hair follicle development GO:0001942 ISS
    negative regulation of cell population proliferation GO:0008285 ISS
    regulation of smoothened signaling pathway GO:0008589 ISS
    embryonic body morphogenesis GO:0010172 ISS
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IEA
    neural tube development GO:0021915 NAS
    negative regulation of cell migration GO:0030336 IMP
    intraciliary transport GO:0042073 NAS
    positive regulation of cilium assembly GO:0045724 IMP
    embryonic skeletal system morphogenesis GO:0048704 ISS
    cilium assembly GO:0060271 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    negative regulation of neural crest formation GO:0090301 ISS
    regulation of cilium assembly GO:1902017 NAS
    non-motile cilium assembly GO:1905515 IBA
    non-motile cilium assembly GO:1905515 IMP
    negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation GO:2000314 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    cilium GO:0005929 NAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FUZ in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FUZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ESPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
4 BAG6 7917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 OSBPL11 114885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 APEX1 328
Affinity Capture-RNA Homo sapiens
7 RSG1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 DDX11 1663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 VPS13B  
Affinity Capture-MS Homo sapiens
11 UBE3A 7337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 UBL4A 8266
Affinity Capture-MS Homo sapiens
14 ACTR6  
Affinity Capture-MS Homo sapiens
15 PTGES2 80142
Affinity Capture-MS Homo sapiens
16 GET4 51608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 OSBPL9 114883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 UBR4 23352
Affinity Capture-MS Homo sapiens
20 NCAPG 64151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 INTU  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FUZ is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Signal Transduction TAS Reactome
Signaling by Hedgehog TAS Reactome





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