Gene description for ITGB7
Gene name integrin, beta 7
Gene symbol ITGB7
Other names/aliases -
Species Homo sapiens
 Database cross references - ITGB7
ExoCarta ExoCarta_3695
Vesiclepedia VP_3695
Entrez Gene 3695
HGNC 6162
MIM 147559
UniProt P26010  
 ITGB7 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for ITGB7
Molecular Function
    protein binding GO:0005515 IPI
    cell adhesion molecule binding GO:0050839 IMP
    metal ion binding GO:0046872 IEA
    virus receptor activity GO:0001618 IEA
Biological Process
    cell-matrix adhesion involved in ameboidal cell migration GO:0003366 IMP
    heterotypic cell-cell adhesion GO:0034113 IMP
    integrin-mediated signaling pathway GO:0007229 IMP
    receptor clustering GO:0043113 IMP
    cell adhesion GO:0007155 TAS
    leukocyte tethering or rolling GO:0050901 IMP
    T cell migration GO:0072678 IEA
    regulation of immune response GO:0050776 TAS
    viral entry into host cell GO:0046718 IEA
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    cell-matrix adhesion GO:0007160 IMP
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    integrin alpha4-beta7 complex GO:0034669 IDA
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    integrin complex GO:0008305 TAS
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified ITGB7 in exosomes
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for ITGB7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invivo Homo sapiens
2 MADCAM1  
Invivo Homo sapiens
Invitro Homo sapiens
3 EED  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 FLNA  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here