Gene description for ITGB7
Gene name integrin, beta 7
Gene symbol ITGB7
Other names/aliases -
Species Homo sapiens
 Database cross references - ITGB7
ExoCarta ExoCarta_3695
Vesiclepedia VP_3695
Entrez Gene 3695
HGNC 6162
MIM 147559
UniProt P26010  
 ITGB7 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for ITGB7
Molecular Function
    virus receptor activity GO:0001618 IEA
    integrin binding GO:0005178 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 IMP
Biological Process
    immune response in gut-associated lymphoid tissue GO:0002387 NAS
    cell-matrix adhesion involved in ameboidal cell migration GO:0003366 IMP
    cell adhesion GO:0007155 TAS
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IDA
    cell-matrix adhesion GO:0007160 IMP
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 IMP
    integrin-mediated signaling pathway GO:0007229 NAS
    cell adhesion mediated by integrin GO:0033627 IBA
    heterotypic cell-cell adhesion GO:0034113 IMP
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    receptor clustering GO:0043113 IMP
    symbiont entry into host cell GO:0046718 IEA
    leukocyte migration GO:0050900 IBA
    leukocyte tethering or rolling GO:0050901 IMP
    T cell migration GO:0072678 IEA
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IBA
    integrin complex GO:0008305 IBA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    membrane GO:0016020 HDA
    integrin alpha4-beta7 complex GO:0034669 IDA
    integrin alpha4-beta7 complex GO:0034669 IPI
    receptor complex GO:0043235 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ITGB7 in sEVs
1
Experiment ID 79
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for ITGB7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Affinity Capture-Western Homo sapiens
2 PLEKHA3  
Affinity Capture-MS Homo sapiens
3 GZMK  
Affinity Capture-MS Homo sapiens
4 MANEA 79694
Affinity Capture-MS Homo sapiens
5 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
6 PTEN 5728
Affinity Capture-MS Homo sapiens
7 CDH1 999
Negative Genetic Homo sapiens
8 CANX 821
Affinity Capture-MS Homo sapiens
9 SFXN3 81855
Affinity Capture-MS Homo sapiens
10 FLNA 2316
Reconstituted Complex Homo sapiens
11 MADCAM1  
Reconstituted Complex Homo sapiens
12 LMAN2L 81562
Affinity Capture-MS Homo sapiens
13 EED  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
14 ATE1 11101
Affinity Capture-MS Homo sapiens
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