Gene description for Erbb4
Gene name v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Gene symbol Erbb4
Other names/aliases Her4
Species Mus musculus
 Database cross references - Erbb4
ExoCarta ExoCarta_13869
Entrez Gene 13869
UniProt Q61527  
 Erbb4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Erbb4
Molecular Function
    nucleotide binding GO:0000166 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    receptor signaling protein tyrosine kinase activity GO:0004716 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    kinase activity GO:0016301 IEA
    epidermal growth factor receptor binding GO:0005154 ISO
    protein homodimerization activity GO:0042803 ISO
    protein tyrosine kinase activity GO:0004713 ISO
    protein kinase activity GO:0004672 IEA
    transferase activity GO:0016740 IEA
Biological Process
    apoptotic process GO:0006915 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    embryonic pattern specification GO:0009880 IMP
    protein autophosphorylation GO:0046777 ISO
    positive regulation of cell migration GO:0030335 ISO
    mammary gland alveolus development GO:0060749 IMP
    mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    cell migration GO:0016477 ISO
    positive regulation of epithelial cell proliferation GO:0050679 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    positive regulation of cardiac muscle cell proliferation GO:0060045 IMP
    synapse maturation GO:0060074 ISO
    positive regulation of synaptic transmission, GABAergic GO:0032230 ISO
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 ISO
    protein phosphorylation GO:0006468 IEA
    multicellular organismal development GO:0007275 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    heart development GO:0007507 IMP
    cardiac muscle tissue regeneration GO:0061026 IMP
    positive regulation of STAT protein import into nucleus GO:2000366 ISO
    positive regulation of glucose import GO:0046326 ISO
    central nervous system morphogenesis GO:0021551 IMP
    signal transduction GO:0007165 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of muscle cell apoptotic process GO:0010656 ISO
    cell fate commitment GO:0045165 IDA
    negative regulation of apoptotic process GO:0043066 ISO
    nervous system development GO:0007399 IMP
    regulation of cell migration GO:0030334 IMP
    mammary gland epithelial cell differentiation GO:0060644 IMP
    surfactant homeostasis GO:0043129 ISO
    lactation GO:0007595 ISO
    phosphorylation GO:0016310 IEA
    neural crest cell migration GO:0001755 IMP
    olfactory bulb interneuron differentiation GO:0021889 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    integral component of membrane GO:0016021 IEA
    caveola GO:0005901 ISO
    membrane raft GO:0045121 ISO
    basolateral plasma membrane GO:0016323 ISO
    mitochondrion GO:0005739 ISO
    plasma membrane GO:0005886 ISO
    postsynaptic density GO:0014069 ISO
    membrane GO:0016020 IEA
    receptor complex GO:0043235 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Erbb4 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Erbb4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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