Gene description for MICU1
Gene name mitochondrial calcium uptake 1
Gene symbol MICU1
Other names/aliases CALC
CBARA1
EFHA3
MPXPS
Species Homo sapiens
 Database cross references - MICU1
ExoCarta ExoCarta_10367
Vesiclepedia VP_10367
Entrez Gene 10367
HGNC 1530
MIM 605084
UniProt Q9BPX6  
 MICU1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MICU1
Molecular Function
    calcium channel regulator activity GO:0005246 IDA
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
    calcium channel inhibitor activity GO:0019855 IDA
    identical protein binding GO:0042802 IPI
    protein heterodimerization activity GO:0046982 IPI
    calcium ion sensor activity GO:0061891 IDA
    calcium ion sensor activity GO:0061891 ISS
Biological Process
    mitochondrial calcium ion transmembrane transport GO:0006851 IDA
    mitochondrial calcium ion transmembrane transport GO:0006851 IMP
    defense response GO:0006952 TAS
    calcium import into the mitochondrion GO:0036444 IBA
    calcium import into the mitochondrion GO:0036444 IDA
    calcium import into the mitochondrion GO:0036444 IMP
    calcium import into the mitochondrion GO:0036444 ISS
    calcium import into the mitochondrion GO:0036444 NAS
    protein homooligomerization GO:0051260 IDA
    mitochondrial calcium ion homeostasis GO:0051560 IBA
    mitochondrial calcium ion homeostasis GO:0051560 IDA
    mitochondrial calcium ion homeostasis GO:0051560 IMP
    mitochondrial calcium ion homeostasis GO:0051560 NAS
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IDA
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IMP
    calcium ion import GO:0070509 IDA
    cellular response to calcium ion GO:0071277 IDA
    cellular response to calcium ion starvation GO:0072732 IDA
    regulation of cellular hyperosmotic salinity response GO:1900069 IMP
    positive regulation of cristae formation GO:1903852 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISS
    mitochondrion GO:0005739 TAS
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IMP
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial membrane GO:0031966 IDA
    calcium channel complex GO:0034704 ISS
    mitochondrial crista junction GO:0044284 IDA
    uniplex complex GO:1990246 IBA
    uniplex complex GO:1990246 IDA
    uniplex complex GO:1990246 IPI
    uniplex complex GO:1990246 ISS
    uniplex complex GO:1990246 NAS
 Experiment description of studies that identified MICU1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MICU1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 AFG3L2 10939
Affinity Capture-MS Homo sapiens
6 FAM131B  
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 PHB2 11331
Proximity Label-MS Homo sapiens
9 SV2A 9900
Affinity Capture-MS Homo sapiens
10 ZCCHC10  
Affinity Capture-MS Homo sapiens
11 SLC18A1  
Affinity Capture-MS Homo sapiens
12 SLC25A12 8604
Proximity Label-MS Homo sapiens
13 AIFM1 9131
Proximity Label-MS Homo sapiens
14 CXCR4 7852
Affinity Capture-MS Homo sapiens
15 THUMPD3 25917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DOCK5 80005
Affinity Capture-MS Homo sapiens
17 DCAF8L2  
Affinity Capture-MS Homo sapiens
18 CD79B 974
Affinity Capture-MS Homo sapiens
19 APOO 79135
Proximity Label-MS Homo sapiens
20 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 AURKB 9212
Affinity Capture-MS Homo sapiens
22 MICU3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PDHA1 5160
Proximity Label-MS Homo sapiens
24 MAGEA1  
Affinity Capture-MS Homo sapiens
25 CUL3 8452
Affinity Capture-MS Homo sapiens
26 RLN1  
Affinity Capture-MS Homo sapiens
27 PKD1L2  
Affinity Capture-MS Homo sapiens
28 DCAF11  
Affinity Capture-MS Homo sapiens
29 CD79A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SFXN1 94081
Proximity Label-MS Homo sapiens
31 EIF2B5 8893
Affinity Capture-MS Homo sapiens
32 APP 351
Reconstituted Complex Homo sapiens
33 CENPA  
Proximity Label-MS Homo sapiens
34 MICU2 221154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PCDHB11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 BABAM1 29086
Affinity Capture-MS Homo sapiens
37 DIABLO 56616
Proximity Label-MS Homo sapiens
38 CPVL 54504
Affinity Capture-MS Homo sapiens
39 ARL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 C12orf49  
Negative Genetic Homo sapiens
41 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TUBA1B 10376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 NEFM 4741
Cross-Linking-MS (XL-MS) Homo sapiens
44 TBC1D22A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ATP2A1 487
Affinity Capture-MS Homo sapiens
46 OGT 8473
Reconstituted Complex Homo sapiens
47 COQ9  
Affinity Capture-MS Homo sapiens
48 SLC25A51  
Proximity Label-MS Homo sapiens
49 KLHL22 84861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TEX19  
Affinity Capture-MS Homo sapiens
51 DNAJC30  
Proximity Label-MS Homo sapiens
52 ANGEL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RANBP6 26953
Affinity Capture-MS Homo sapiens
54 AKAP1 8165
Proximity Label-MS Homo sapiens
55 AARS 16
Affinity Capture-MS Homo sapiens
56 APEX1 328
Affinity Capture-RNA Homo sapiens
57 COX4I1 1327
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MICU1 is involved
PathwayEvidenceSource
Mitochondrial calcium ion transport TAS Reactome
Processing of SMDT1 TAS Reactome
Transport of small molecules TAS Reactome





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