Gene description for MAT1A
Gene name methionine adenosyltransferase I, alpha
Gene symbol MAT1A
Other names/aliases MAT
MATA1
SAMS
SAMS1
Species Homo sapiens
 Database cross references - MAT1A
ExoCarta ExoCarta_4143
Entrez Gene 4143
HGNC 6903
MIM 610550
UniProt Q00266  
 MAT1A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MAT1A
Molecular Function
    ATP binding GO:0005524 IEA
    methionine adenosyltransferase activity GO:0004478 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    methylation GO:0032259 TAS
    sulfur amino acid metabolic process GO:0000096 TAS
    xenobiotic metabolic process GO:0006805 TAS
    one-carbon metabolic process GO:0006730 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    cellular amino acid metabolic process GO:0006520 TAS
    S-adenosylmethionine biosynthetic process GO:0006556 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified MAT1A in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MAT1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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