Gene description for Ptpn12
Gene name protein tyrosine phosphatase, non-receptor type 12
Gene symbol Ptpn12
Other names/aliases P19-PTP
PTP-P19
PTP-PEST
PTPG1
Species Mus musculus
 Database cross references - Ptpn12
ExoCarta ExoCarta_19248
Entrez Gene 19248
UniProt P35831  
 Ptpn12 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ptpn12
Molecular Function
    SH3 domain binding GO:0017124 ISO
    protein binding GO:0005515 IPI
    phosphatase activity GO:0016791 IEA
    phosphoprotein phosphatase activity GO:0004721 IDA
    protein tyrosine phosphatase activity GO:0004725 ISO
    hydrolase activity GO:0016787 IEA
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 ISO
    protein dephosphorylation GO:0006470 IDA
    dephosphorylation GO:0016311 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    cytosol GO:0005829 IDA
    cell projection GO:0042995 IEA
    cytoplasm GO:0005737 ISO
    podosome GO:0002102 IDA
    cell junction GO:0030054 IEA
 Experiment description of studies that identified Ptpn12 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ptpn12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SHC1 6464
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Ptpn12 is involved
No pathways found





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