Gene description for DDR2
Gene name discoidin domain receptor tyrosine kinase 2
Gene symbol DDR2
Other names/aliases MIG20a
NTRKR3
TKT
TYRO10
Species Homo sapiens
 Database cross references - DDR2
ExoCarta ExoCarta_4921
Entrez Gene 4921
HGNC 2731
MIM 191311
UniProt Q16832  
 DDR2 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Prostate cancer cells 25844599    
 Gene ontology annotations for DDR2
Molecular Function
    protein tyrosine kinase collagen receptor activity GO:0038062 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    collagen binding GO:0005518 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
Biological Process
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    biomineral tissue development GO:0031214 ISS
    positive regulation of fibroblast proliferation GO:0048146 ISS
    positive regulation of extracellular matrix disassembly GO:0090091 ISS
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP
    endochondral bone growth GO:0003416 ISS
    signal transduction GO:0007165 TAS
    cell adhesion GO:0007155 TAS
    positive regulation of fibroblast migration GO:0010763 TAS
    protein autophosphorylation GO:0046777 IDA
    extracellular matrix organization GO:0030198 TAS
    positive regulation of osteoblast differentiation GO:0045669 IMP
    collagen fibril organization GO:0030199 ISS
    ossification GO:0001503 IEA
    regulation of bone mineralization GO:0030500 IMP
    regulation of extracellular matrix disassembly GO:0010715 TAS
    chondrocyte proliferation GO:0035988 TAS
    positive regulation of protein kinase activity GO:0045860 IMP
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 IEA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IDA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified DDR2 in exosomes
1
Experiment ID 260
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for DDR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SHC1 6464
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 COL1A1 1277
Invitro Homo sapiens
3 COL3A1 1281
Invitro Homo sapiens
4 SRC 6714
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which DDR2 is involved
PathwayEvidenceSource
Non-integrin membrane-ECM interactions TAS Reactome





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