Experiment description of studies that identified SHANK2 in exosomes

1 Experiment ID 237 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH EV Cytosolic markers ✘ EV Membrane markers ✔ HSP90B1 EV Negative markers ✔ qNano EV Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N Journal name Carcinogenesis Publication year 2015 Sample Hepatocytes Sample name MIHA Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RNA Sequencing

Protein-protein interactions for SHANK2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 ARHGEF7 8874 Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 2 LPHN1   Invivo Homo sapiens Invitro Homo sapiens 3 ADGRL2 23266 Invitro Homo sapiens Two-hybrid Homo sapiens Invitro Homo sapiens Invivo Homo sapiens Two-hybrid Homo sapiens 4 DLGAP1   Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 5 DNM2 1785 Invitro Homo sapiens Invivo Homo sapiens Two-hybrid Homo sapiens 6 DYNLL2 140735 Affinity Capture-Western Homo sapiens 7 CTTN 2017 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 8 MYO5A 4644 Affinity Capture-Western Homo sapiens 9 BAI2   Two-hybrid Homo sapiens 10 DLG4   Affinity Capture-Western Homo sapiens 11 DYNLL1 8655 Affinity Capture-Western Homo sapiens 12 SSTR2   Invitro Homo sapiens View the network

Pathways in which SHANK2 is involved

No pathways found