Gene description for SHANK2
Gene name SH3 and multiple ankyrin repeat domains 2
Gene symbol SHANK2
Other names/aliases AUTS17
Species Homo sapiens
 Database cross references - SHANK2
ExoCarta ExoCarta_22941
Entrez Gene 22941
HGNC 14295
MIM 603290
UniProt Q9UPX8  
 SHANK2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SHANK2
Molecular Function
    GKAP/Homer scaffold activity GO:0030160 NAS
    SH3 domain binding GO:0017124 IEA
    ionotropic glutamate receptor binding GO:0035255 ISS
    protein binding GO:0005515 IPI
Biological Process
    memory GO:0007613 IEA
    long-term synaptic potentiation GO:0060291 ISS
    synapse assembly GO:0007416 ISS
    long term synaptic depression GO:0060292 ISS
    social behavior GO:0035176 IMP
    adult behavior GO:0030534 IMP
    learning GO:0007612 IMP
    vocalization behavior GO:0071625 IMP
    exploration behavior GO:0035640 IEA
Subcellular Localization
    photoreceptor outer segment GO:0001750 ISS
    neuronal cell body GO:0043025 ISS
    postsynaptic density GO:0014069 ISS
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 ISS
    neurofilament GO:0005883 ISS
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 ISS
    dendritic spine GO:0043197 ISS
    growth cone GO:0030426 ISS
    postsynaptic membrane GO:0045211 ISS
    neuron projection GO:0043005 ISS
    ciliary membrane GO:0060170 ISS
    ionotropic glutamate receptor complex GO:0008328 ISS
    cell junction GO:0030054 IEA
    photoreceptor inner segment GO:0001917 ISS
 Experiment description of studies that identified SHANK2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SHANK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARHGEF7 8874
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 LPHN1  
Invivo Homo sapiens
Invitro Homo sapiens
3 ADGRL2 23266
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 DLGAP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 DNM2 1785
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
6 DYNLL2 140735
Affinity Capture-Western Homo sapiens
7 CTTN 2017
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 MYO5A 4644
Affinity Capture-Western Homo sapiens
9 BAI2  
Two-hybrid Homo sapiens
10 DLG4  
Affinity Capture-Western Homo sapiens
11 DYNLL1 8655
Affinity Capture-Western Homo sapiens
12 SSTR2  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SHANK2 is involved
No pathways found

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