Gene description for Dynlt3
Gene name dynein light chain Tctex-type 3
Gene symbol Dynlt3
Other names/aliases 2310075M16Rik
AU042796
Tcte1l
Species Mus musculus
 Database cross references - Dynlt3
ExoCarta ExoCarta_67117
Vesiclepedia VP_67117
Entrez Gene 67117
UniProt P56387  
 Dynlt3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dynlt3
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    dynein intermediate chain binding GO:0045505 IBA
Biological Process
    microtubule-based movement GO:0007018 IBA
    regulation of mitotic cell cycle GO:0007346 ISS
    positive regulation of mitotic cell cycle GO:0045931 IEA
    positive regulation of mitotic cell cycle GO:0045931 ISO
    cell division GO:0051301 IEA
Subcellular Localization
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISO
    kinetochore GO:0000776 ISS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasmic dynein complex GO:0005868 IBA
    cytoplasmic dynein complex GO:0005868 ISO
    cytoplasmic dynein complex GO:0005868 ISS
    mitotic spindle astral microtubule GO:0061673 IEA
    mitotic spindle astral microtubule GO:0061673 ISO
 Experiment description of studies that identified Dynlt3 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dynlt3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dctn2 69654
Co-fractionation Mus musculus
2 Dync1i2  
Co-fractionation Mus musculus
3 Vdac1 22333
Co-fractionation Mus musculus
4 Clasp2  
Co-fractionation Mus musculus
5 Tpr 108989
Co-fractionation Mus musculus
6 Apc  
Co-fractionation Mus musculus
7 Serbp1 66870
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Dynlt3 is involved
No pathways found





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