Gene description for Vdac1
Gene name voltage-dependent anion channel 1
Gene symbol Vdac1
Other names/aliases AL033343
Vdac5
Species Mus musculus
 Database cross references - Vdac1
ExoCarta ExoCarta_22333
Vesiclepedia VP_22333
Entrez Gene 22333
UniProt Q60932  
 Vdac1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vdac1
Molecular Function
    protein complex binding GO:0032403 ISO
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    porin activity GO:0015288 IEA
    anion channel activity GO:0005253 ISO
    voltage-gated anion channel activity GO:0008308 ISO
    protein kinase binding GO:0019901 ISO
Biological Process
    neuron-neuron synaptic transmission GO:0007270 IMP
    behavioral fear response GO:0001662 IMP
    regulation of anion transmembrane transport GO:1903959 ISO
    transport GO:0006810 IEA
    regulation of anion transport GO:0044070 IEA
    transmembrane transport GO:0055085 IEA
    anion transmembrane transport GO:0098656 ISO
    apoptotic process GO:0006915 IEA
    anion transport GO:0006820 IEA
    mitochondrial calcium ion transport GO:0006851 ISO
    synaptic transmission GO:0007268 IMP
    learning GO:0007612 IMP
    ion transport GO:0006811 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    integral component of membrane GO:0016021 IEA
    mitochondrial outer membrane GO:0005741 ISS
    pore complex GO:0046930 IEA
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 IEA
    synaptic vesicle GO:0008021 ISO
    protein complex GO:0043234 ISO
    mitochondrion GO:0005739 ISO
    myelin sheath GO:0043209 IDA
    mitochondrial nucleoid GO:0042645 ISO
    mitochondrial inner membrane GO:0005743 ISS
 Experiment description of studies that identified Vdac1 in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vdac1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vdac1 is involved
PathwayEvidenceSource
Mitochondrial protein import IEA Reactome





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