Gene description for Cycs
Gene name cytochrome c, somatic
Gene symbol Cycs
Other names/aliases -
Species Mus musculus
 Database cross references - Cycs
ExoCarta ExoCarta_13063
Entrez Gene 13063
UniProt P62897  
 Cycs identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cycs
Molecular Function
    electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity GO:0045155 ISO
    electron carrier activity GO:0009055 ISO
    heme binding GO:0020037 IDA
Biological Process
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IBA
    apoptotic DNA fragmentation GO:0006309 ISO
    hydrogen peroxide metabolic process GO:0042743 IDA
    ATP synthesis coupled electron transport GO:0042773 IBA
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 IBA
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 IMP
    apoptotic process GO:0006915 IDA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial intermembrane space GO:0005758 IBA
    cytosol GO:0005829 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Cycs in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cycs
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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