Gene description for Cox4i1
Gene name cytochrome c oxidase subunit IV isoform 1
Gene symbol Cox4i1
Other names/aliases AL024441
COX
COX IV-1
COXIV
Cox4
Cox4a
IV-1
Species Mus musculus
 Database cross references - Cox4i1
ExoCarta ExoCarta_12857
Vesiclepedia VP_12857
Entrez Gene 12857
UniProt P19783  
 Cox4i1 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Cox4i1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IDA
    cytosol GO:0005829 IDA
    mitochondrial membrane GO:0031966 IDA
    mitochondrial membrane GO:0031966 ISO
    respiratory chain complex IV GO:0045277 IBA
    respiratory chain complex IV GO:0045277 IDA
    respiratory chain complex IV GO:0045277 ISO
 Experiment description of studies that identified Cox4i1 in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cox4i1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sco1  
Co-fractionation Mus musculus
2 Etfdh  
Cross-Linking-MS (XL-MS) Mus musculus
3 Cox4i1 12857
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
4 Got2 14719
Cross-Linking-MS (XL-MS) Mus musculus
5 Atp5j  
Cross-Linking-MS (XL-MS) Mus musculus
6 Ndufb5  
Co-fractionation Mus musculus
7 Ndufc2  
Co-fractionation Mus musculus
8 Agxt2  
Cross-Linking-MS (XL-MS) Mus musculus
9 Slc25a3 18674
Co-fractionation Mus musculus
10 Ndufb3  
Cross-Linking-MS (XL-MS) Mus musculus
11 Cycs 13063
Cross-Linking-MS (XL-MS) Mus musculus
12 Uqcrh  
Cross-Linking-MS (XL-MS) Mus musculus
13 Atp5f1  
Co-fractionation Mus musculus
14 Kctd13  
Affinity Capture-MS Mus musculus
15 Cox6c  
Cross-Linking-MS (XL-MS) Mus musculus
16 Cox7b  
Cross-Linking-MS (XL-MS) Mus musculus
17 Cox7c  
Cross-Linking-MS (XL-MS) Mus musculus
18 Atp5b 11947
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
19 Atp5o 28080
Cross-Linking-MS (XL-MS) Mus musculus
20 Tmem173  
Proximity Label-MS Mus musculus
21 Atp5a1 11946
Cross-Linking-MS (XL-MS) Mus musculus
22 Auh  
Cross-Linking-MS (XL-MS) Mus musculus
23 Sdha 66945
Cross-Linking-MS (XL-MS) Mus musculus
Co-fractionation Mus musculus
24 Cpt2  
Cross-Linking-MS (XL-MS) Mus musculus
25 Cox5b 12859
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
26 Ndufb10  
Co-fractionation Mus musculus
27 Fastkd2  
Cross-Linking-MS (XL-MS) Mus musculus
28 Ndufa4  
Cross-Linking-MS (XL-MS) Mus musculus
29 Ndufs2  
Co-fractionation Mus musculus
30 Uqcr10  
Co-fractionation Mus musculus
31 Slc25a4 11739
Cross-Linking-MS (XL-MS) Mus musculus
32 Ndufb6  
Co-fractionation Mus musculus
33 Mdh2 17448
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



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