Gene description for Atp5b
Gene name ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
Gene symbol Atp5b
Other names/aliases -
Species Mus musculus
 Database cross references - Atp5b
ExoCarta ExoCarta_11947
Entrez Gene 11947
UniProt P56480  
 Atp5b identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Atp5b
Molecular Function
    lipoprotein particle receptor activity GO:0030228 ISO
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016820 IEA
    proton-transporting ATP synthase activity, rotational mechanism GO:0046933 IEA
    MHC class I protein binding GO:0042288 ISO
    calcium ion binding GO:0005509 ISO
    hydrolase activity GO:0016787 IEA
    ATPase activity GO:0016887 ISO
    ATP binding GO:0005524 ISO
    nucleotide binding GO:0000166 IEA
    proton-transporting ATPase activity, rotational mechanism GO:0046961 ISO
Biological Process
    regulation of intracellular pH GO:0051453 ISO
    osteoblast differentiation GO:0001649 ISO
    lipid metabolic process GO:0006629 IMP
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 IMP
    angiogenesis GO:0001525 ISO
    ATP synthesis coupled proton transport GO:0015986 IEA
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    ATP biosynthetic process GO:0006754 ISO
    proton transport GO:0015992 ISO
    transport GO:0006810 IEA
    ion transport GO:0006811 IEA
    receptor-mediated endocytosis GO:0006898 ISO
    ATP metabolic process GO:0046034 ISO
    hydrogen ion transmembrane transport GO:1902600 ISO
Subcellular Localization
    cell surface GO:0009986 ISO
    proton-transporting ATP synthase complex, catalytic core F(1) GO:0045261 ISO
    mitochondrial membrane GO:0031966 ISO
    plasma membrane GO:0005886 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) GO:0000275 ISO
    mitochondrial inner membrane GO:0005743 ISO
    myelin sheath GO:0043209 IDA
    mitochondrial proton-transporting ATP synthase complex GO:0005753 ISO
    proton-transporting two-sector ATPase complex, catalytic domain GO:0033178 IEA
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
    mitochondrial nucleoid GO:0042645 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Atp5b in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp5b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here