Gene description for Acadm
Gene name acyl-Coenzyme A dehydrogenase, medium chain
Gene symbol Acadm
Other names/aliases AU018656
MCAD
Species Mus musculus
 Database cross references - Acadm
ExoCarta ExoCarta_11364
Entrez Gene 11364
UniProt P45952  
 Acadm identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Acadm
Molecular Function
    medium-chain-acyl-CoA dehydrogenase activity GO:0070991 ISO
    oxidoreductase activity GO:0016491 IEA
    acyl-CoA dehydrogenase activity GO:0003995 ISO
    oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 IEA
    identical protein binding GO:0042802 ISO
    fatty-acyl-CoA binding GO:0000062 ISO
    flavin adenine dinucleotide binding GO:0050660 ISO
    isomerase activity GO:0016853 ISO
Biological Process
    glycogen biosynthetic process GO:0005978 IMP
    fatty acid metabolic process GO:0006631 IEA
    organic acid metabolic process GO:0006082 IMP
    response to cold GO:0009409 IMP
    lipid metabolic process GO:0006629 IEA
    protein homotetramerization GO:0051289 ISO
    medium-chain fatty acid metabolic process GO:0051791 ISO
    heart development GO:0007507 IMP
    oxidation-reduction process GO:0055114 ISO
    cardiac muscle cell differentiation GO:0055007 IMP
    medium-chain fatty acid catabolic process GO:0051793 ISO
    metabolic process GO:0008152 IEA
    response to starvation GO:0042594 IMP
    carnitine metabolic process GO:0009437 IMP
    regulation of gluconeogenesis GO:0006111 IMP
    post-embryonic development GO:0009791 IMP
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISO
    liver development GO:0001889 IMP
    fatty acid beta-oxidation GO:0006635 ISO
    carnitine metabolic process, CoA-linked GO:0019254 ISO
    carnitine biosynthetic process GO:0045329 ISO
Subcellular Localization
    mitochondrial matrix GO:0005759 ISO
    mitochondrial membrane GO:0031966 ISO
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
    axon GO:0030424 ISO
 Experiment description of studies that identified Acadm in exosomes
1
Experiment ID 263
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Acadm
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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