Gene description for Aco2
Gene name aconitase 2, mitochondrial
Gene symbol Aco2
Other names/aliases Aco-2
Aco3
D10Wsu183e
Species Mus musculus
 Database cross references - Aco2
ExoCarta ExoCarta_11429
Entrez Gene 11429
UniProt Q99KI0  
 Aco2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Aco2
Molecular Function
    aconitate hydratase activity GO:0003994 ISO
    metal ion binding GO:0046872 IEA
    lyase activity GO:0016829 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 ISO
    3 iron, 4 sulfur cluster binding GO:0051538 ISO
    iron ion binding GO:0005506 ISO
    iron-sulfur cluster binding GO:0051536 IEA
Biological Process
    citrate metabolic process GO:0006101 ISO
    metabolic process GO:0008152 IEA
    tricarboxylic acid cycle GO:0006099 ISO
    isocitrate metabolic process GO:0006102 ISO
Subcellular Localization
    myelin sheath GO:0043209 IDA
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Aco2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aco2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aco2 is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) IEA Reactome





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