Gene description for Aco2
Gene name aconitase 2, mitochondrial
Gene symbol Aco2
Other names/aliases Aco-2
Aco3
D10Wsu183e
Species Mus musculus
 Database cross references - Aco2
ExoCarta ExoCarta_11429
Entrez Gene 11429
UniProt Q99KI0  
 Aco2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Aco2
Molecular Function
    aconitate hydratase activity GO:0003994 ISO
    metal ion binding GO:0046872 IEA
    lyase activity GO:0016829 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 ISO
    3 iron, 4 sulfur cluster binding GO:0051538 ISO
    iron ion binding GO:0005506 ISO
    iron-sulfur cluster binding GO:0051536 IEA
Biological Process
    citrate metabolic process GO:0006101 ISO
    metabolic process GO:0008152 IEA
    tricarboxylic acid cycle GO:0006099 ISO
    isocitrate metabolic process GO:0006102 ISO
Subcellular Localization
    myelin sheath GO:0043209 IDA
    mitochondrion GO:0005739 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Aco2 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aco2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aco2 is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) IEA Reactome





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