Gene description for Acadvl
Gene name acyl-Coenzyme A dehydrogenase, very long chain
Gene symbol Acadvl
Other names/aliases vlcad
Species Mus musculus
 Database cross references - Acadvl
ExoCarta ExoCarta_11370
Vesiclepedia VP_11370
Entrez Gene 11370
UniProt P50544  
 Acadvl identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Acadvl
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IBA
    fatty-acyl-CoA binding GO:0000062 ISO
    acyl-CoA dehydrogenase activity GO:0003995 ISO
    acyl-CoA dehydrogenase activity GO:0003995 ISS
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IEA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 ISO
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IBA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 ISO
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 ISS
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    flavin adenine dinucleotide binding GO:0050660 ISO
    flavin adenine dinucleotide binding GO:0050660 ISS
Biological Process
    temperature homeostasis GO:0001659 IMP
    fatty acid beta-oxidation GO:0006635 ISO
    fatty acid catabolic process GO:0009062 IMP
    response to cold GO:0009409 IMP
    epithelial cell differentiation GO:0030855 IEA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IMP
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISO
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISS
    negative regulation of fatty acid biosynthetic process GO:0045717 IMP
    negative regulation of fatty acid oxidation GO:0046322 IMP
    regulation of cholesterol metabolic process GO:0090181 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial membrane GO:0031966 ISO
    mitochondrial nucleoid GO:0042645 IEA
    mitochondrial nucleoid GO:0042645 ISO
 Experiment description of studies that identified Acadvl in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Acadvl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Got2 14719
Cross-Linking-MS (XL-MS) Mus musculus
2 Slc25a3 18674
Cross-Linking-MS (XL-MS) Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Acadvl 11370
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
5 Etfa 110842
Cross-Linking-MS (XL-MS) Mus musculus
6 Socs3  
Affinity Capture-Western Mus musculus
7 Atg5  
Affinity Capture-RNA Mus musculus
8 Slc25a4 11739
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
9 HSD17B10 3028
Affinity Capture-MS Homo sapiens
10 Atp5h 71679
Cross-Linking-MS (XL-MS) Mus musculus
11 Mdh2 17448
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
12 Aco2 11429
Cross-Linking-MS (XL-MS) Mus musculus
13 Cox7a1  
Cross-Linking-MS (XL-MS) Mus musculus
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