Gene description for Slc25a4
Gene name solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
Gene symbol Slc25a4
Other names/aliases AU019225
Ant1
Species Mus musculus
 Database cross references - Slc25a4
ExoCarta ExoCarta_11739
Entrez Gene 11739
UniProt P48962  
 Slc25a4 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Slc25a4
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISO
    transporter activity GO:0005215 IEA
Biological Process
    negative regulation of necroptotic process GO:0060546 ISO
    apoptotic mitochondrial changes GO:0008637 IGI
    transmembrane transport GO:0055085 IEA
    negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902109 ISO
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 ISO
    transport GO:0006810 IEA
    positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 ISO
    positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 ISO
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IEA
    myelin sheath GO:0043209 IDA
    nucleus GO:0005634 ISO
    mitochondrial outer membrane GO:0005741 ISS
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 ISS
 Experiment description of studies that identified Slc25a4 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc25a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARL2BP  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Slc25a4 is involved
PathwayEvidenceSource
Mitochondrial protein import IEA Reactome
Regulation of insulin secretion IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here