Gene description for Got2
Gene name glutamatic-oxaloacetic transaminase 2, mitochondrial
Gene symbol Got2
Other names/aliases AL022787
FABP-pm
Got-2
mAspAT
Species Mus musculus
 Database cross references - Got2
ExoCarta ExoCarta_14719
Entrez Gene 14719
UniProt P05202  
 Got2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Got2
Molecular Function
    carboxylic acid binding GO:0031406 ISO
    phospholipid binding GO:0005543 ISO
    enzyme binding GO:0019899 ISO
    transaminase activity GO:0008483 IEA
    kynurenine-oxoglutarate transaminase activity GO:0016212 IEA
    amino acid binding GO:0016597 ISO
    L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069 ISO
    L-phenylalanine:2-oxoglutarate aminotransferase activity GO:0080130 IEA
    transferase activity GO:0016740 IEA
    poly(A) RNA binding GO:0044822 ISO
    pyridoxal phosphate binding GO:0030170 ISO
    catalytic activity GO:0003824 IEA
    protein homodimerization activity GO:0042803 ISO
Biological Process
    aspartate metabolic process GO:0006531 ISO
    aspartate catabolic process GO:0006533 ISO
    transport GO:0006810 IEA
    response to ethanol GO:0045471 ISO
    lipid transport GO:0006869 IEA
    aspartate biosynthetic process GO:0006532 IDA
    glutamate catabolic process to 2-oxoglutarate GO:0019551 IDA
    dicarboxylic acid metabolic process GO:0043648 ISO
    glutamate catabolic process to aspartate GO:0019550 IDA
    oxaloacetate metabolic process GO:0006107 IDA
    biosynthetic process GO:0009058 IEA
    cellular amino acid metabolic process GO:0006520 ISO
Subcellular Localization
    perikaryon GO:0043204 ISO
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
    myelin sheath GO:0043209 IDA
    protein complex GO:0043234 ISO
    plasma membrane GO:0005886 ISO
    mitochondrial inner membrane GO:0005743 ISO
 Experiment description of studies that identified Got2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Got2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Got2 is involved
PathwayEvidenceSource
Amino acid synthesis and interconversion (transamination) IEA Reactome
Gluconeogenesis IEA Reactome





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