Gene description for Vdac3
Gene name voltage-dependent anion channel 3
Gene symbol Vdac3
Other names/aliases -
Species Mus musculus
 Database cross references - Vdac3
ExoCarta ExoCarta_22335
Vesiclepedia VP_22335
Entrez Gene 22335
UniProt Q60931  
 Vdac3 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Vdac3
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    voltage-gated monoatomic anion channel activity GO:0008308 IBA
    voltage-gated monoatomic anion channel activity GO:0008308 IEA
    porin activity GO:0015288 IEA
Biological Process
    behavioral fear response GO:0001662 IMP
    chemical synaptic transmission GO:0007268 IMP
    neuron-neuron synaptic transmission GO:0007270 IMP
    spermatogenesis GO:0007283 IMP
    learning GO:0007612 IMP
    monoatomic anion transmembrane transport GO:0098656 IEA
    sperm mitochondrial sheath assembly GO:0120317 IMP
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial inner membrane GO:0005743 HDA
    synaptic vesicle GO:0008021 ISO
    membrane GO:0016020 ISO
    synapse GO:0045202 IEA
    pore complex GO:0046930 IEA
 Experiment description of studies that identified Vdac3 in sEVs
1
Experiment ID 188
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vdac3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sdha 66945
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Slc26a8  
Co-fractionation Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
5 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
6 Atp5a1 11946
Co-fractionation Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Csrp3  
Co-fractionation Mus musculus
9 Rps5 20103
Co-fractionation Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Slc25a4 11739
Co-fractionation Mus musculus
12 Ndufv2  
Co-fractionation Mus musculus
13 Ndufs4  
Co-fractionation Mus musculus
14 Fancd2  
Affinity Capture-MS Mus musculus
15 Vdac3 22335
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
16 Tomm70a  
Co-fractionation Mus musculus
View the network image/svg+xml



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