Gene description for Prdx3
Gene name peroxiredoxin 3
Gene symbol Prdx3
Other names/aliases AW822249
Aop1
D0Tohi1
Ef2l
Mer5
Prx3
SP22
TDXM
Species Mus musculus
 Database cross references - Prdx3
ExoCarta ExoCarta_11757
Entrez Gene 11757
UniProt P20108  
 Prdx3 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Prdx3
Molecular Function
    protein kinase binding GO:0019901 ISO
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO
    peroxidase activity GO:0004601 IEA
    thioredoxin peroxidase activity GO:0008379 ISO
    antioxidant activity GO:0016209 IEA
    identical protein binding GO:0042802 IPI
    protein C-terminus binding GO:0008022 ISO
    kinase binding GO:0019900 ISO
    peroxiredoxin activity GO:0051920 IEA
    oxidoreductase activity GO:0016491 IEA
Biological Process
    positive regulation of cell proliferation GO:0008284 ISO
    mitochondrion organization GO:0007005 ISO
    hydrogen peroxide catabolic process GO:0042744 ISO
    regulation of mitochondrial membrane potential GO:0051881 ISO
    peptidyl-cysteine oxidation GO:0018171 ISO
    response to oxidative stress GO:0006979 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    cellular response to oxidative stress GO:0034599 ISO
    response to lipopolysaccharide GO:0032496 IMP
    oxidation-reduction process GO:0055114 IEA
    response to hydrogen peroxide GO:0042542 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of neuron apoptotic process GO:0043524 ISO
    cellular response to reactive oxygen species GO:0034614 ISO
    myeloid cell differentiation GO:0030099 IMP
    negative regulation of kinase activity GO:0033673 ISO
    maternal placenta development GO:0001893 IMP
    apoptotic process GO:0006915 ISO
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    early endosome GO:0005769 ISO
    cytoplasm GO:0005737 ISO
    IkappaB kinase complex GO:0008385 ISO
    myelin sheath GO:0043209 IDA
 Experiment description of studies that identified Prdx3 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prdx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prdx3 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome





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