Gene description for RBL2
Gene name retinoblastoma-like 2
Gene symbol RBL2
Other names/aliases P130
Rb2
Species Homo sapiens
 Database cross references - RBL2
ExoCarta ExoCarta_5934
Vesiclepedia VP_5934
Entrez Gene 5934
HGNC 9894
MIM 180203
UniProt Q08999  
 RBL2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for RBL2
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    protein binding GO:0005515 IPI
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    chromatin organization GO:0006325 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    negative regulation of gene expression GO:0010629 IMP
    cell differentiation GO:0030154 IBA
    regulation of lipid kinase activity GO:0043550 IDA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IBA
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IBA
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RBL2 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PHB 5245
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 CITED1 4435
Affinity Capture-MS Homo sapiens
3 MCM7 4176
Reconstituted Complex Homo sapiens
4 Ccnd3  
Protein-peptide Mus musculus
5 CUL1 8454
Affinity Capture-Western Homo sapiens
6 BRF1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 XBP1  
Two-hybrid Homo sapiens
8 CCND2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 USP4 7375
Reconstituted Complex Homo sapiens
10 AATF  
Affinity Capture-Western Homo sapiens
11 CTBP1 1487
Affinity Capture-Western Homo sapiens
12 CCNB1 891
Affinity Capture-MS Homo sapiens
13 LBX1  
Two-hybrid Homo sapiens
14 TP53BP1 7158
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
15 DYRK1B  
Affinity Capture-MS Homo sapiens
16 CCND1 595
Two-hybrid Homo sapiens
17 E2F5  
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
18 DCTN1 1639
Two-hybrid Homo sapiens
19 E2F1 1869
Affinity Capture-Western Homo sapiens
20 BRCA1 672
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
21 SKP1 6500
Affinity Capture-Western Homo sapiens
22 SKP2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
23 CCNE1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 PPP1R9B 84687
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
25 HBP1  
Two-hybrid Homo sapiens
26 SERPINB2 5055
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
29 CDK6 1021
Biochemical Activity Homo sapiens
30 TAF1  
Affinity Capture-Western Homo sapiens
31 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RBBP9 10741
Affinity Capture-Western Homo sapiens
33 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
34 RAD50 10111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 TFDP1  
Affinity Capture-MS Homo sapiens
36 CDKN1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CDK2 1017
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
38 LIN52  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 E2F4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
40 CCNA2 890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
41 LIN9  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
42 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
43 SREBF2 6721
Positive Genetic Homo sapiens
44 CDK4 1019
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
45 TFDP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RINT1 60561
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
47 DCAF7 10238
Affinity Capture-MS Homo sapiens
48 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
49 LDHC 3948
Two-hybrid Homo sapiens
50 TP63  
Synthetic Rescue Homo sapiens
51 TOP1 7150
Protein-peptide Homo sapiens
52 LIN54  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
53 PPP2CA 5515
Reconstituted Complex Homo sapiens
54 PCBD1 5092
Two-hybrid Homo sapiens
55 RAF1 5894
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 CCNA1  
Reconstituted Complex Homo sapiens
57 SNW1 22938
Reconstituted Complex Homo sapiens
58 SUV39H1  
Affinity Capture-Western Homo sapiens
59 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
60 CYCS 54205
Affinity Capture-MS Homo sapiens
61 RBL1  
Affinity Capture-Western Homo sapiens
62 GRAMD4 23151
Two-hybrid Homo sapiens
63 SMARCA4 6597
Two-hybrid Homo sapiens
64 FOXK1 221937
Affinity Capture-MS Homo sapiens
65 DGKZ  
Affinity Capture-Western Homo sapiens
66 LIN37  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
67 IRF3 3661
Affinity Capture-MS Homo sapiens
68 RARG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CCND3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
70 TXNDC11 51061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RBBP8  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 ID2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 DYRK1A 1859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RBL2 is involved
PathwayEvidenceSource
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
FOXO-mediated transcription IEA Reactome
FOXO-mediated transcription of cell cycle genes IEA Reactome
G0 and Early G1 TAS Reactome
G0 and Early G1 IEA Reactome
G1 Phase TAS Reactome
G1/S Transition TAS Reactome
G1/S Transition IEA Reactome
G1/S-Specific Transcription TAS Reactome
G1/S-Specific Transcription IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
S Phase TAS Reactome
TP53 Regulates Transcription of Cell Cycle Genes TAS Reactome
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TAS Reactome
Transcription of E2F targets under negative control by DREAM complex TAS Reactome
Transcription of E2F targets under negative control by DREAM complex IEA Reactome
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 IEA Reactome
Transcriptional Regulation by TP53 TAS Reactome





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