Gene description for TXNDC11
Gene name thioredoxin domain containing 11
Gene symbol TXNDC11
Other names/aliases EFP1
Species Homo sapiens
 Database cross references - TXNDC11
ExoCarta ExoCarta_51061
Entrez Gene 51061
HGNC 28030
UniProt Q6PKC3  
 TXNDC11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TXNDC11
Molecular Function
    protein disulfide isomerase activity GO:0003756 IBA
    protein binding GO:0005515 IPI
Biological Process
    cell redox homeostasis GO:0045454 IEA
    response to endoplasmic reticulum stress GO:0034976 IBA
    protein folding GO:0006457 IBA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified TXNDC11 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TXNDC11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT15 3866
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TXNDC11 is involved
No pathways found

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