Gene description for CDKN2B
Gene name	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Gene symbol	CDKN2B
Other names/aliases	CDK4I INK4B MTS2 P15 TP15 p15INK4b
Species	Homo sapiens
Database cross references - CDKN2B
ExoCarta	ExoCarta_1030
Entrez Gene	1030
HGNC	1788
MIM	600431
UniProt	P42772
CDKN2B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for CDKN2B

Molecular Function     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 NAS     protein kinase binding GO:0019901 IPI     protein binding GO:0005515 IPI Biological Process     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     negative regulation of cell proliferation GO:0008285 IMP     regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IDA     cellular response to nutrient GO:0031670 IMP     mitotic cell cycle GO:0000278 TAS     positive regulation of epithelial cell differentiation GO:0030858 IEA     cell cycle arrest GO:0007050 IMP     cellular response to extracellular stimulus GO:0031668 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     G2/M transition of mitotic cell cycle GO:0000086 IMP     transcription, DNA-templated GO:0006351 TAS     response to cytokine GO:0034097 IEA     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP     negative regulation of phosphorylation GO:0042326 IDA     negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     response to organic cyclic compound GO:0014070 IEA     aging GO:0007568 IEA     mitotic cell cycle checkpoint GO:0007093 IMP     gene expression GO:0010467 TAS     negative regulation of protein serine/threonine kinase activity GO:0071901 NAS     megakaryocyte differentiation GO:0030219 IEP     liver development GO:0001889 IEA     negative regulation of epithelial cell proliferation GO:0050680 IMP     spleen development GO:0048536 IEA Subcellular Localization     cytosol GO:0005829 TAS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IDA