Gene description for DUSP12
Gene name dual specificity phosphatase 12
Gene symbol DUSP12
Other names/aliases DUSP1
YVH1
Species Homo sapiens
 Database cross references - DUSP12
ExoCarta ExoCarta_11266
Vesiclepedia VP_11266
Entrez Gene 11266
HGNC 3067
MIM 604835
UniProt Q9UNI6  
 DUSP12 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DUSP12
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IEA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    kinase binding GO:0019900 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 TAS
Biological Process
    positive regulation of glucokinase activity GO:0033133 IBA
    cellular protein modification process GO:0006464 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified DUSP12 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DUSP12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIAA1377  
Two-hybrid Homo sapiens
2 RABAC1 10567
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 MBD6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DUSP12 is involved
No pathways found





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