Gene description for DUSP12
Gene name dual specificity phosphatase 12
Gene symbol DUSP12
Other names/aliases DUSP1
YVH1
Species Homo sapiens
 Database cross references - DUSP12
ExoCarta ExoCarta_11266
Vesiclepedia VP_11266
Entrez Gene 11266
HGNC 3067
MIM 604835
UniProt Q9UNI6  
 DUSP12 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DUSP12
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 TAS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    zinc ion binding GO:0008270 IDA
    phosphatase activity GO:0016791 IDA
    myosin phosphatase activity GO:0017018 IEA
    kinase binding GO:0019900 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    dephosphorylation GO:0016311 IDA
    protein modification process GO:0036211 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified DUSP12 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DUSP12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTN  
Two-hybrid Homo sapiens
2 AGL 178
Co-fractionation Homo sapiens
3 NDUFA11 126328
Affinity Capture-MS Homo sapiens
4 MBD6  
Two-hybrid Homo sapiens
5 NCK1 4690
Affinity Capture-MS Homo sapiens
6 CCNH  
Two-hybrid Homo sapiens
7 MBLAC2 153364
Affinity Capture-MS Homo sapiens
8 TMEM208  
Affinity Capture-MS Homo sapiens
9 EIF6 3692
Proximity Label-MS Homo sapiens
10 MAPK1 5594
Affinity Capture-MS Homo sapiens
11 DUSP3 1845
Affinity Capture-MS Homo sapiens
12 DFFA 1676
Affinity Capture-MS Homo sapiens
13 CD6 923
Affinity Capture-MS Homo sapiens
14 HRAS 3265
Affinity Capture-MS Homo sapiens
15 APRT 353
Affinity Capture-MS Homo sapiens
16 TMEM126A 84233
Affinity Capture-MS Homo sapiens
17 TROVE2 6738
Affinity Capture-MS Homo sapiens
18 PSMD10 5716
Affinity Capture-MS Homo sapiens
19 KIAA1377  
Two-hybrid Homo sapiens
20 TMEM11 8834
Affinity Capture-MS Homo sapiens
21 PARK7 11315
Affinity Capture-MS Homo sapiens
22 MOCS2  
Co-fractionation Homo sapiens
23 XYLB 9942
Co-fractionation Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 C21orf59 56683
Co-fractionation Homo sapiens
26 DUSP13  
Affinity Capture-MS Homo sapiens
27 EIF2D 1939
Affinity Capture-MS Homo sapiens
28 DUSP12 11266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 C17orf64  
Affinity Capture-MS Homo sapiens
30 LACRT 90070
Affinity Capture-MS Homo sapiens
31 TBCB 1155
Affinity Capture-MS Homo sapiens
32 RABAC1 10567
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 AK6  
Affinity Capture-MS Homo sapiens
34 USO1 8615
Two-hybrid Homo sapiens
35 GPR151  
Affinity Capture-MS Homo sapiens
36 ALDH6A1 4329
Affinity Capture-MS Homo sapiens
37 AKR7A2 8574
Co-fractionation Homo sapiens
38 DCTN1 1639
Affinity Capture-MS Homo sapiens
39 DUSP4 1846
Affinity Capture-MS Homo sapiens
40 PPP2R3B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 EIF5A 1984
Affinity Capture-MS Homo sapiens
42 ACP1 52
Affinity Capture-MS Homo sapiens
43 ARF5 381
Affinity Capture-MS Homo sapiens
44 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
45 RAB28 9364
Affinity Capture-MS Homo sapiens
46 NR1H2  
Two-hybrid Homo sapiens
47 TPM4 7171
Affinity Capture-MS Homo sapiens
48 HSPB8 26353
Two-hybrid Homo sapiens
49 PPM1A 5494
Affinity Capture-MS Homo sapiens
50 EIF5 1983
Two-hybrid Homo sapiens
51 VPS4A 27183
Affinity Capture-MS Homo sapiens
52 HDDC2 51020
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DUSP12 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here