Gene description for ITGB6
Gene name integrin, beta 6
Gene symbol ITGB6
Other names/aliases AI1H
Species Homo sapiens
 Database cross references - ITGB6
ExoCarta ExoCarta_3694
Entrez Gene 3694
HGNC 6161
MIM 147558
UniProt P18564  
 ITGB6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for ITGB6
Molecular Function
    virus receptor activity GO:0001618 IEA
    integrin binding GO:0005178 IEA
Biological Process
    extracellular matrix organization GO:0030198 TAS
    inflammatory response GO:0006954 IEA
    cell adhesion GO:0007155 TAS
    integrin-mediated signaling pathway GO:0007229 IEA
    cell-matrix adhesion GO:0007160 IEA
    viral entry into host cell GO:0046718 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integrin complex GO:0008305 IEA
    extracellular exosome GO:0070062 IDA
    receptor complex GO:0043235 IDA
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified ITGB6 in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITGB6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invitro Homo sapiens
Invitro Homo sapiens
2 FLNB 2317
Two-hybrid Homo sapiens
3 FHL2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 ITGAV 3685
Invivo Homo sapiens
5 TNC 3371
Invivo Homo sapiens
Invivo Homo sapiens
6 FLNA  
Two-hybrid Homo sapiens
View the network image/svg+xml



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