Gene description for GNPTAB
Gene name N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Gene symbol GNPTAB
Other names/aliases GNPTA
ICD
Species Homo sapiens
 Database cross references - GNPTAB
ExoCarta ExoCarta_79158
Vesiclepedia VP_79158
Entrez Gene 79158
HGNC 29670
MIM 607840
UniProt Q3T906  
 GNPTAB identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for GNPTAB
Molecular Function
    transcription factor binding GO:0008134 IEA
    protein binding GO:0005515 IPI
    UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 IMP
    calcium ion binding GO:0005509 IEA
Biological Process
    lysosome organization GO:0007040 IMP
    cell differentiation GO:0030154 IEA
    N-glycan processing to lysosome GO:0016256 IMP
    protein secretion GO:0009306 IEA
    carbohydrate phosphorylation GO:0046835 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    Golgi membrane GO:0000139 IDA
    integral component of membrane GO:0016021 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified GNPTAB in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GNPTAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GNPTAB is involved
No pathways found





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