Gene description for TGFBR3
Gene name transforming growth factor, beta receptor III
Gene symbol TGFBR3
Other names/aliases BGCAN
betaglycan
Species Homo sapiens
 Database cross references - TGFBR3
ExoCarta ExoCarta_7049
Vesiclepedia VP_7049
Entrez Gene 7049
HGNC 11774
MIM 600742
UniProt Q03167  
 TGFBR3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for TGFBR3
Molecular Function
    coreceptor activity GO:0015026 IDA
    SMAD binding GO:0046332 IMP
    protein binding GO:0005515 IPI
    glycosaminoglycan binding GO:0005539 TAS
    transforming growth factor beta receptor binding GO:0005160 ISS
    fibroblast growth factor binding GO:0017134 IEA
    PDZ domain binding GO:0030165 ISS
    transforming growth factor beta-activated receptor activity GO:0005024 IDA
    activin binding GO:0048185 IEA
    transforming growth factor beta receptor activity, type III GO:0070123 IDA
    transforming growth factor beta binding GO:0050431 IPI
    type II transforming growth factor beta receptor binding GO:0005114 IDA
    heparin binding GO:0008201 ISS
Biological Process
    heart morphogenesis GO:0003007 ISS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    response to hypoxia GO:0001666 IEA
    cell growth GO:0016049 ISS
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IEA
    response to luteinizing hormone GO:0034699 IDA
    definitive erythrocyte differentiation GO:0060318 ISS
    cardiac muscle cell proliferation GO:0060038 ISS
    pathway-restricted SMAD protein phosphorylation GO:0060389 IMP
    negative regulation of epithelial cell migration GO:0010633 IEA
    immune response GO:0006955 IMP
    palate development GO:0060021 ISS
    epithelial to mesenchymal transition GO:0001837 IDA
    cell migration GO:0016477 ISS
    blood vessel development GO:0001568 IEA
    negative regulation of epithelial cell proliferation GO:0050680 ISS
    response to follicle-stimulating hormone GO:0032354 IDA
    definitive hemopoiesis GO:0060216 ISS
    transforming growth factor beta receptor complex assembly GO:0007181 IEA
    negative regulation of epithelial to mesenchymal transition GO:0010719 IEA
    regulation of protein binding GO:0043393 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    intracellular signal transduction GO:0035556 IMP
    organ regeneration GO:0031100 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IEA
    heart trabecula formation GO:0060347 ISS
    cardiac epithelial to mesenchymal transition GO:0060317 IDA
    ventricular cardiac muscle tissue morphogenesis GO:0055010 ISS
    BMP signaling pathway GO:0030509 IDA
    blastocyst development GO:0001824 IEA
    negative regulation of cellular component movement GO:0051271 IDA
    liver development GO:0001889 ISS
    response to prostaglandin E GO:0034695 IDA
Subcellular Localization
    cell surface GO:0009986 ISS
    inhibin-betaglycan-ActRII complex GO:0034673 IDA
    external side of plasma membrane GO:0009897 IDA
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 ISS
    proteinaceous extracellular matrix GO:0005578 IEA
    endoplasmic reticulum GO:0005783 IEA
    extracellular space GO:0005615 TAS
    receptor complex GO:0043235 IDA
 Experiment description of studies that identified TGFBR3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
8
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TGFBR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFB1 7040
Affinity Capture-Western Homo sapiens
2 TGFBR2 7048
Affinity Capture-Western Homo sapiens
3 TGFB3 7043
Invitro Homo sapiens
4 GIPC1 10755
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TGFBR3 is involved
No pathways found





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