Gene description for IGFALS
Gene name insulin-like growth factor binding protein, acid labile subunit
Gene symbol IGFALS
Other names/aliases ACLSD
ALS
Species Homo sapiens
 Database cross references - IGFALS
ExoCarta ExoCarta_3483
Entrez Gene 3483
HGNC 5468
MIM 601489
UniProt P35858  
 IGFALS identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Urine 19056867    
 Gene ontology annotations for IGFALS
Molecular Function
    insulin-like growth factor binding GO:0005520 TAS
Biological Process
    signal transduction GO:0007165 TAS
    cellular protein metabolic process GO:0044267 TAS
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified IGFALS in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for IGFALS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGF1  
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
2 IGFBP5 3488
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 IGFBP3  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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