Gene description for OGN
Gene name osteoglycin
Gene symbol OGN
Other names/aliases OG
Species Homo sapiens
 Database cross references - OGN
ExoCarta ExoCarta_4969
Entrez Gene 4969
HGNC 8126
MIM 602383
UniProt P20774  
 OGN identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for OGN
Molecular Function
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
Biological Process
    small molecule metabolic process GO:0044281 TAS
    carbohydrate metabolic process GO:0005975 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    keratan sulfate catabolic process GO:0042340 TAS
    negative regulation of smooth muscle cell proliferation GO:0048662 ISS
    keratan sulfate metabolic process GO:0042339 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    proteinaceous extracellular matrix GO:0005578 IEA
    Golgi lumen GO:0005796 TAS
    lysosomal lumen GO:0043202 TAS
    extracellular space GO:0005615 IDA
    extracellular vesicle GO:1903561 IDA
    extracellular exosome GO:0070062 IDA
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified OGN in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for OGN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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