Gene description for SCPEP1
Gene name serine carboxypeptidase 1
Gene symbol SCPEP1
Other names/aliases HSCP1
RISC
Species Homo sapiens
 Database cross references - SCPEP1
ExoCarta ExoCarta_59342
Entrez Gene 59342
HGNC 29507
UniProt Q9HB40  
 SCPEP1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for SCPEP1
Molecular Function
    serine-type carboxypeptidase activity GO:0004185 ISS
Biological Process
    proteolysis GO:0006508 IEA
    negative regulation of blood pressure GO:0045776 ISS
    positive regulation of vasodilation GO:0045909 ISS
    retinoic acid metabolic process GO:0042573 ISS
Subcellular Localization
    cytosol GO:0005829 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SCPEP1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SCPEP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SCPEP1 is involved
No pathways found





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