Gene description for BLOC1S5
Gene name biogenesis of lysosomal organelles complex-1, subunit 5, muted
Gene symbol BLOC1S5
Other names/aliases BLOS5
MU
MUTED
Species Homo sapiens
 Database cross references - BLOC1S5
ExoCarta ExoCarta_63915
Vesiclepedia VP_63915
Entrez Gene 63915
HGNC 18561
MIM 607289
UniProt Q8TDH9  
 BLOC1S5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Saliva 19199708    
 Gene ontology annotations for BLOC1S5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    melanosome organization GO:0032438 NAS
    endosome to melanosome transport GO:0035646 IDA
    melanosome transport GO:0032402 IDA
    otolith morphogenesis GO:0032474 IEA
    anterograde synaptic vesicle transport GO:0048490 ISS
    neuron projection development GO:0031175 ISS
    anterograde axon cargo transport GO:0008089 ISS
    positive regulation of pigment cell differentiation GO:0050942 IDA
Subcellular Localization
    transport vesicle GO:0030133 IDA
    BLOC-1 complex GO:0031083 IDA
 Experiment description of studies that identified BLOC1S5 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for BLOC1S5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DTNBP1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 BLOC1S3 388552
Affinity Capture-Western Homo sapiens
3 BLOC1S2 282991
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 PLDN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which BLOC1S5 is involved
No pathways found





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