Gene description for ABI3
Gene name ABI family, member 3
Gene symbol ABI3
Other names/aliases NESH
SSH3BP3
Species Homo sapiens
 Database cross references - ABI3
ExoCarta ExoCarta_51225
Vesiclepedia VP_51225
Entrez Gene 51225
HGNC 29859
MIM 606363
UniProt Q9P2A4  
 ABI3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ABI3
Molecular Function
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 IBA
    identical protein binding GO:0042802 IPI
    actin filament binding GO:0051015 ISS
Biological Process
    neuron migration GO:0001764 IBA
    defense response to tumor cell GO:0002357 IMP
    negative regulation of lamellipodium assembly GO:0010593 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    actin cytoskeleton organization GO:0030036 ISS
    regulation of cell migration GO:0030334 IBA
    regulation of cell migration GO:0030334 IDA
    cell projection morphogenesis GO:0048858 IBA
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    modification of postsynaptic actin cytoskeleton GO:0098885 IEA
    regulation of postsynaptic density assembly GO:0099151 ISS
    negative regulation of ruffle assembly GO:1900028 NAS
    negative regulation of protein localization to plasma membrane GO:1903077 ISS
    positive regulation of cellular senescence GO:2000774 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 NAS
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 HDA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    SCAR complex GO:0031209 IBA
    SCAR complex GO:0031209 IDA
    dendritic spine GO:0043197 ISS
    dendritic shaft GO:0043198 ISS
    actin-based cell projection GO:0098858 IBA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ABI3 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ABI3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT24 192666
Two-hybrid Homo sapiens
2 HOMER1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 SUFU 51684
Two-hybrid Homo sapiens
4 ABI3 51225
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 NCK2 8440
Two-hybrid Homo sapiens
6 FBF1  
Two-hybrid Homo sapiens
7 CEP170P1  
Two-hybrid Homo sapiens
8 GRB2 2885
Two-hybrid Homo sapiens
9 SNAP23 8773
Two-hybrid Homo sapiens
10 CCDC36  
Two-hybrid Homo sapiens
11 IFT20 90410
Two-hybrid Homo sapiens
12 BAIAP2L2 80115
Two-hybrid Homo sapiens
13 PAK1 5058
Reconstituted Complex Homo sapiens
14 WASF2 10163
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 ARMC7  
Two-hybrid Homo sapiens
16 KRT35 3886
Two-hybrid Homo sapiens
17 FARSA 2193
Two-hybrid Homo sapiens
18 TMEM147 10430
Two-hybrid Homo sapiens
19 PAK2 5062
Reconstituted Complex Homo sapiens
20 NUPL1 9818
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 KIFC3 3801
Two-hybrid Homo sapiens
22 WASF1 8936
Two-hybrid Homo sapiens
23 KRT28 162605
Two-hybrid Homo sapiens
24 ABI3BP 25890
Two-hybrid Homo sapiens
25 ACTN3 89
Two-hybrid Homo sapiens
26 KRT36 8689
Two-hybrid Homo sapiens
27 VARS2  
Two-hybrid Homo sapiens
28 RUNX1T1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 VASP 7408
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 KRT38 8687
Two-hybrid Homo sapiens
31 BFSP2  
Two-hybrid Homo sapiens
32 PSMA1 5682
Two-hybrid Homo sapiens
33 MRFAP1L1  
Two-hybrid Homo sapiens
34 CEP44  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 KRT15 3866
Two-hybrid Homo sapiens
36 WAS 7454
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 DTNBP1  
Two-hybrid Homo sapiens
38 ABI2 10152
Two-hybrid Homo sapiens
39 HOMER2  
Two-hybrid Homo sapiens
40 BLOC1S5 63915
Two-hybrid Homo sapiens
41 EMILIN1 11117
Two-hybrid Homo sapiens
42 ENAH 55740
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
43 STX1A 6804
Two-hybrid Homo sapiens
44 KLC3  
Two-hybrid Homo sapiens
45 DTNB 1838
Two-hybrid Homo sapiens
46 WASH1 100287171
Two-hybrid Homo sapiens
47 MRFAP1  
Two-hybrid Homo sapiens
48 KANK2 25959
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 NDEL1 81565
Two-hybrid Homo sapiens
50 KRT14 3861
Two-hybrid Homo sapiens
51 KRT13 3860
Two-hybrid Homo sapiens
52 EIF3M 10480
Two-hybrid Homo sapiens
53 GOLM1 51280
Two-hybrid Homo sapiens
54 MIS18A  
Two-hybrid Homo sapiens
55 OIP5  
Two-hybrid Homo sapiens
56 MAGEA12  
Two-hybrid Homo sapiens
57 EVL 51466
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 FAM124B  
Two-hybrid Homo sapiens
59 ARHGAP9 64333
Two-hybrid Homo sapiens
60 AGTR1  
Two-hybrid Homo sapiens
61 KIAA0408  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 NHSL2  
Two-hybrid Homo sapiens
63 KLC4 89953
Two-hybrid Homo sapiens
64 GNG13  
Two-hybrid Homo sapiens
65 EIF3H 8667
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
66 STX2 2054
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ABI3 is involved
No pathways found





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