Gene description for BAIAP2L2
Gene name BAI1-associated protein 2-like 2
Gene symbol BAIAP2L2
Other names/aliases -
Species Homo sapiens
 Database cross references - BAIAP2L2
ExoCarta ExoCarta_80115
Entrez Gene 80115
HGNC 26203
UniProt Q6UXY1  
 BAIAP2L2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BAIAP2L2
Molecular Function
    cytoskeletal adaptor activity GO:0008093 IBA
    phospholipid binding GO:0005543 ISS
Biological Process
    actin filament bundle assembly GO:0051017 IBA
    membrane organization GO:0061024 ISS
    plasma membrane organization GO:0007009 IEA
    actin crosslink formation GO:0051764 IBA
    insulin receptor signaling pathway GO:0008286 IBA
    positive regulation of actin cytoskeleton reorganization GO:2000251 IBA
    positive regulation of actin filament polymerization GO:0030838 IBA
Subcellular Localization
    cell-cell contact zone GO:0044291 IDA
    nucleoplasm GO:0005654 IBA
    vesicle membrane GO:0012506 IDA
    actin cytoskeleton GO:0015629 IBA
    plasma membrane GO:0005886 IEA
    clathrin complex GO:0071439 IDA
    cytosol GO:0005829 IBA
    cytoplasmic vesicle membrane GO:0030659 IEA
 Experiment description of studies that identified BAIAP2L2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BAIAP2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BAIAP2L2 is involved
No pathways found





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