Gene description for BAIAP2L2
Gene name BAI1-associated protein 2-like 2
Gene symbol BAIAP2L2
Other names/aliases -
Species Homo sapiens
 Database cross references - BAIAP2L2
ExoCarta ExoCarta_80115
Vesiclepedia VP_80115
Entrez Gene 80115
HGNC 26203
UniProt Q6UXY1  
 BAIAP2L2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for BAIAP2L2
Molecular Function
    phospholipid binding GO:0005543 ISS
Biological Process
    plasma membrane organization GO:0007009 IEA
    positive regulation of actin filament polymerization GO:0030838 IBA
    actin filament bundle assembly GO:0051017 IBA
    actin crosslink formation GO:0051764 IBA
    membrane organization GO:0061024 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    vesicle membrane GO:0012506 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    cell-cell contact zone GO:0044291 IDA
    clathrin complex GO:0071439 IDA
 Experiment description of studies that identified BAIAP2L2 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BAIAP2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM9B  
Two-hybrid Homo sapiens
2 GRXCR1  
Two-hybrid Homo sapiens
3 ABI3 51225
Two-hybrid Homo sapiens
4 GLYCTK  
Two-hybrid Homo sapiens
5 GABPB1  
Two-hybrid Homo sapiens
View the network image/svg+xml



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