Gene description for TOE1
Gene name target of EGR1, member 1 (nuclear)
Gene symbol TOE1
Other names/aliases -
Species Homo sapiens
 Database cross references - TOE1
ExoCarta ExoCarta_114034
Entrez Gene 114034
HGNC 15954
MIM 613931
UniProt Q96GM8  
 TOE1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for TOE1
Molecular Function
    protein binding GO:0005515 IPI
    nucleic acid binding GO:0003676 IEA
    metal ion binding GO:0046872 IEA
Subcellular Localization
    nucleolus GO:0005730 IEA
    nucleus GO:0005634 IDA
    nuclear speck GO:0016607 IEA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified TOE1 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TOE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNU11 26824
Affinity Capture-MS Homo sapiens
2 ABCF3 55324
Two-hybrid Homo sapiens
3 SH3GL3  
Two-hybrid Homo sapiens
4 APLP1  
Two-hybrid Homo sapiens
5 Dnaja2  
Two-hybrid Rattus norvegicus
6 RPS3A 6189
Two-hybrid Homo sapiens
7 SUMO1 7341
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TOE1 is involved
No pathways found





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