Gene description for CCL2
Gene name	chemokine (C-C motif) ligand 2
Gene symbol	CCL2
Other names/aliases	GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF
Species	Homo sapiens
Database cross references - CCL2
ExoCarta	ExoCarta_6347
Vesiclepedia	VP_6347
Entrez Gene	6347
HGNC	10618
MIM	158105
UniProt	P13500
CCL2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for CCL2

Molecular Function     protein kinase activity GO:0004672 TAS     signaling receptor binding GO:0005102 TAS     protein binding GO:0005515 IPI     chemokine activity GO:0008009 IBA     CCR2 chemokine receptor binding GO:0031727 ISS     CCR2 chemokine receptor binding GO:0031727 TAS     CCR chemokine receptor binding GO:0048020 IBA Biological Process     angiogenesis GO:0001525 TAS     monocyte chemotaxis GO:0002548 IDA     protein phosphorylation GO:0006468 TAS     chemotaxis GO:0006935 TAS     inflammatory response GO:0006954 IBA     humoral immune response GO:0006959 TAS     cytoskeleton organization GO:0007010 IDA     cell adhesion GO:0007155 TAS     signal transduction GO:0007165 NAS     cell surface receptor signaling pathway GO:0007166 TAS     G protein-coupled receptor signaling pathway GO:0007186 TAS     G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS     cell surface receptor signaling pathway via JAK-STAT GO:0007259 TAS     regulation of cell shape GO:0008360 IDA     response to bacterium GO:0009617 NAS     animal organ morphogenesis GO:0009887 TAS     viral genome replication GO:0019079 TAS     cytokine-mediated signaling pathway GO:0019221 IDA     sensory perception of pain GO:0019233 ISS     cellular homeostasis GO:0019725 TAS     positive regulation of cell migration GO:0030335 IBA     negative regulation of glial cell apoptotic process GO:0034351 IDA     helper T cell extravasation GO:0035684 ISS     negative regulation of neuron apoptotic process GO:0043524 IDA     astrocyte cell migration GO:0043615 IDA     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     eosinophil chemotaxis GO:0048245 IBA     macrophage chemotaxis GO:0048246 IDA     positive regulation of T cell activation GO:0050870 ISS     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA     chemokine-mediated signaling pathway GO:0070098 IBA     cellular response to lipopolysaccharide GO:0071222 ISS     cellular response to type II interferon GO:0071346 IEP     cellular response to type II interferon GO:0071346 ISS     cellular response to interleukin-1 GO:0071347 IEP     cellular response to interleukin-1 GO:0071347 ISS     cellular response to tumor necrosis factor GO:0071356 IEP     cellular response to tumor necrosis factor GO:0071356 ISS     positive regulation of calcium ion import GO:0090280 IDA     positive regulation of NMDA glutamate receptor activity GO:1904783 ISS     negative regulation of vascular endothelial cell proliferation GO:1905563 IMP     negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IMP     positive regulation of endothelial cell apoptotic process GO:2000353 IMP     positive regulation of apoptotic cell clearance GO:2000427 ISS     negative regulation of natural killer cell chemotaxis GO:2000502 IDA Subcellular Localization     extracellular region GO:0005576 IDA     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA