Gene description for ASGR1
Gene name asialoglycoprotein receptor 1
Gene symbol ASGR1
Other names/aliases ASGPR
Species Homo sapiens
 Database cross references - ASGR1
ExoCarta ExoCarta_432
Entrez Gene 432
HGNC 742
MIM 108360
UniProt P07306  
 ASGR1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ASGR1
Molecular Function
    metal ion binding GO:0046872 IEA
    carbohydrate binding GO:0030246 IEA
    asialoglycoprotein receptor activity GO:0004873 TAS
    protein binding GO:0005515 IPI
Biological Process
    receptor-mediated endocytosis GO:0006898 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified ASGR1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ASGR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSP90AA1 3320
Invivo Homo sapiens
Invitro Homo sapiens
2 TG  
Invivo Homo sapiens
3 ASGR2  
Invivo Homo sapiens
4 HSP90B1 7184
Invivo Homo sapiens
5 LASS2  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ASGR1 is involved
No pathways found

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