Gene description for HLA-H
Gene name major histocompatibility complex, class I, H (pseudogene)
Gene symbol HLA-H
Other names/aliases HLAHP
Species Homo sapiens
 Database cross references - HLA-H
ExoCarta ExoCarta_3136
Entrez Gene 3136
HGNC 4965
 HLA-H identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for HLA-H
Molecular Function
    beta-2-microglobulin binding GO:0030881 IMP
    peptide antigen binding GO:0042605 IEA
Biological Process
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    immune response GO:0006955 NAS
Subcellular Localization
    cell surface GO:0009986 IMP
    integral component of plasma membrane GO:0005887 NAS
    MHC class I protein complex GO:0042612 IEA
 Experiment description of studies that identified HLA-H in exosomes
1
Experiment ID 21
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for HLA-H
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HLA-H is involved
No pathways found





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