Gene description for HLA-H
Gene name major histocompatibility complex, class I, H (pseudogene)
Gene symbol HLA-H
Other names/aliases HLAHP
Species Homo sapiens
 Database cross references - HLA-H
ExoCarta ExoCarta_3136
Vesiclepedia VP_3136
Entrez Gene 3136
HGNC 4965
 HLA-H identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for HLA-H
Molecular Function
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    beta-2-microglobulin binding GO:0030881 IMP
    peptide antigen binding GO:0042605 IBA
Biological Process
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 IBA
    immune response GO:0006955 IBA
    immune response GO:0006955 NAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IMP
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    phagocytic vesicle membrane GO:0030670 TAS
    early endosome membrane GO:0031901 TAS
    azurophil granule membrane GO:0035577 TAS
    MHC class I protein complex GO:0042612 IEA
    recycling endosome membrane GO:0055038 TAS
    lumenal side of endoplasmic reticulum membrane GO:0098553 TAS
 Experiment description of studies that identified HLA-H in sEVs
1
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for HLA-H
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFTPC  
Affinity Capture-MS Homo sapiens
2 CUL3 8452
Affinity Capture-MS Homo sapiens
3 NR3C1 2908
Affinity Capture-MS Homo sapiens
4 PTPRO 5800
Affinity Capture-MS Homo sapiens
5 RB1CC1 9821
Affinity Capture-MS Homo sapiens
6 HLA-G 3135
Affinity Capture-MS Homo sapiens
7 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HLA-E 3133
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HLA-C 3107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HLA-H is involved
No pathways found





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