Gene description for SULT1A3
Gene name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Gene symbol SULT1A3
Other names/aliases HAST
HAST3
M-PST
ST1A3
ST1A3/ST1A4
ST1A5
STM
TL-PST
Species Homo sapiens
 Database cross references - SULT1A3
ExoCarta ExoCarta_6818
Entrez Gene 6818
HGNC 11455
MIM 600641
UniProt P0DMN0   P0DMM9  
 SULT1A3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SULT1A3
Molecular Function
    aryl sulfotransferase activity GO:0004062 TAS
    protein binding GO:0005515 IPI
    sulfotransferase activity GO:0008146 IDA
Biological Process
    catecholamine metabolic process GO:0006584 IEA
    sulfation GO:0051923 IDA
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    cellular protein metabolic process GO:0044267 TAS
    flavonoid metabolic process GO:0009812 IDA
    xenobiotic metabolic process GO:0006805 TAS
    3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0050427 TAS
    small molecule metabolic process GO:0044281 TAS
    steroid metabolic process GO:0008202 IEA
    IRE1-mediated unfolded protein response GO:0036498 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SULT1A3 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SULT1A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SULT1A3 is involved
PathwayEvidenceSource
Cytosolic sulfonation of small molecules TAS Reactome
XBP1(S) activates chaperone genes TAS Reactome





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