Gene description for PPIG
Gene name peptidylprolyl isomerase G (cyclophilin G)
Gene symbol PPIG
Other names/aliases CARS-Cyp
CYP
SCAF10
SRCyp
Species Homo sapiens
 Database cross references - PPIG
ExoCarta ExoCarta_9360
Vesiclepedia VP_9360
Entrez Gene 9360
HGNC 14650
MIM 606093
UniProt Q13427  
 PPIG identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PPIG
Molecular Function
    RNA binding GO:0003723 HDA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IDA
    protein binding GO:0005515 IPI
    cyclosporin A binding GO:0016018 IBA
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein folding GO:0006457 IBA
    RNA splicing GO:0008380 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear matrix GO:0016363 IEA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified PPIG in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PPIG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 NUF2  
Affinity Capture-MS Homo sapiens
3 IPO7 10527
Co-fractionation Homo sapiens
4 SRPK2 6733
Affinity Capture-MS Homo sapiens
5 SP1  
Reconstituted Complex Homo sapiens
6 PRPF38A 84950
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 ANAPC15  
Affinity Capture-MS Homo sapiens
8 EPB41L3 23136
Affinity Capture-MS Homo sapiens
9 DAB1 1600
Two-hybrid Homo sapiens
10 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
12 PRPF40A 55660
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 SNRPF 6636
Affinity Capture-MS Homo sapiens
14 TRIM54  
Two-hybrid Homo sapiens
15 ANKRD50 57182
Affinity Capture-MS Homo sapiens
16 DDX23 9416
Proximity Label-MS Homo sapiens
17 TKT 7086
Cross-Linking-MS (XL-MS) Homo sapiens
18 RNPS1 10921
Affinity Capture-MS Homo sapiens
19 CEP70  
Two-hybrid Homo sapiens
20 KIF23 9493
Affinity Capture-MS Homo sapiens
21 NFKBIL1  
Affinity Capture-MS Homo sapiens
22 ZMYND11 10771
Affinity Capture-MS Homo sapiens
23 YWHAG 7532
Affinity Capture-MS Homo sapiens
24 SRSF3 6428
Affinity Capture-MS Homo sapiens
25 Polr2a  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
26 SARNP 84324
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MECP2 4204
Affinity Capture-MS Homo sapiens
28 TFCP2 7024
Two-hybrid Homo sapiens
29 MYCN  
Affinity Capture-MS Homo sapiens
30 PPCDC  
Two-hybrid Homo sapiens
31 RPS11 6205
Affinity Capture-MS Homo sapiens
32 SLU7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 DYNLT1 6993
Proximity Label-MS Homo sapiens
34 LARP4B 23185
Affinity Capture-MS Homo sapiens
35 PFN1 5216
Cross-Linking-MS (XL-MS) Homo sapiens
36 CHMP4C 92421
Affinity Capture-MS Homo sapiens
37 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TMEM14B  
Affinity Capture-MS Homo sapiens
39 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
40 FHL3 2275
Two-hybrid Homo sapiens
41 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
42 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MAPRE1 22919
Affinity Capture-MS Homo sapiens
44 SRSF6 6431
Affinity Capture-MS Homo sapiens
45 SNRPB 6628
Affinity Capture-MS Homo sapiens
46 RAD18  
Affinity Capture-MS Homo sapiens
47 PNMA2  
Two-hybrid Homo sapiens
48 MAGEB2 4113
Affinity Capture-MS Homo sapiens
49 SRPK1 6732
Affinity Capture-MS Homo sapiens
50 ANLN 54443
Affinity Capture-MS Homo sapiens
51 TPX2  
Affinity Capture-MS Homo sapiens
52 SRSF11 9295
Affinity Capture-MS Homo sapiens
53 RBBP6 5930
Affinity Capture-MS Homo sapiens
54 ZBTB2 57621
Affinity Capture-MS Homo sapiens
55 RBM39 9584
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
56 CACNA1A  
Two-hybrid Homo sapiens
57 C11orf57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 JPH3 57338
Affinity Capture-MS Homo sapiens
60 PSENEN  
Affinity Capture-MS Homo sapiens
61 PNN 5411
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
62 SRSF4 6429
Affinity Capture-MS Homo sapiens
63 SRSF1 6426
Affinity Capture-MS Homo sapiens
64 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DACH1  
Two-hybrid Homo sapiens
66 SRSF5 6430
Affinity Capture-MS Homo sapiens
67 BEND7 222389
Two-hybrid Homo sapiens
68 ZC3H11A  
Affinity Capture-MS Homo sapiens
69 THAP1  
Two-hybrid Homo sapiens
70 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 PCBP1 5093
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
72 MYC  
Affinity Capture-MS Homo sapiens
73 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 PABPC5 140886
Affinity Capture-MS Homo sapiens
75 CHD8 57680
Affinity Capture-MS Homo sapiens
76 MALL  
Affinity Capture-MS Homo sapiens
77 Ccdc9  
Affinity Capture-MS Mus musculus
78 NKAP 79576
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
79 YBX1 4904
Affinity Capture-MS Homo sapiens
80 GRK5 2869
Affinity Capture-MS Homo sapiens
81 KCTD6  
Two-hybrid Homo sapiens
82 RNF151  
Affinity Capture-MS Homo sapiens
83 SMN1 6606
Two-hybrid Homo sapiens
84 CPSF6 11052
Affinity Capture-MS Homo sapiens
85 MDK 4192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 LGALS3 3958
Two-hybrid Homo sapiens
87 SAP18 10284
Affinity Capture-MS Homo sapiens
88 SNRPA 6626
Affinity Capture-MS Homo sapiens
89 THRAP3 9967
Affinity Capture-MS Homo sapiens
90 IFI6  
Affinity Capture-MS Homo sapiens
91 SMN2 6607
Two-hybrid Homo sapiens
92 EPB41L2 2037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 C20orf197  
Affinity Capture-MS Homo sapiens
94 Srsf1 110809
Affinity Capture-MS Mus musculus
95 SNIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 NCL 4691
Co-fractionation Homo sapiens
97 SRSF7 6432
Affinity Capture-MS Homo sapiens
98 ZCCHC10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 LUC7L 55692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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