Gene description for SMN2
Gene name survival of motor neuron 2, centromeric
Gene symbol SMN2
Other names/aliases BCD541
C-BCD541
GEMIN1
SMNC
TDRD16B
Species Homo sapiens
 Database cross references - SMN2
ExoCarta ExoCarta_6607
Entrez Gene 6607
HGNC 11118
MIM 601627
UniProt Q16637  
 SMN2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SMN2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    RNA binding GO:0003723 IEA
Biological Process
    nervous system development GO:0007399 IEA
    gene expression GO:0010467 TAS
    ncRNA metabolic process GO:0034660 TAS
    spliceosomal complex assembly GO:0000245 NAS
    spliceosomal snRNP assembly GO:0000387 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    SMN complex GO:0032797 IDA
    Z disc GO:0030018 IEA
    spliceosomal complex GO:0005681 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    Cajal body GO:0015030 IDA
    cytosol GO:0005829 TAS
    Gemini of coiled bodies GO:0097504 IDA
    SMN-Sm protein complex GO:0034719 IDA
 Experiment description of studies that identified SMN2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SMN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Invitro Homo sapiens
2 SMN1 6606
Co-purification Homo sapiens
Co-fractionation Homo sapiens
3 SNRPG 6637
Invitro Homo sapiens
4 SNRPF 6636
Invitro Homo sapiens
5 GSK3B 2932
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SMN2 is involved
PathwayEvidenceSource
snRNP Assembly TAS Reactome





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