Gene description for FIP1L1
Gene name factor interacting with PAPOLA and CPSF1
Gene symbol FIP1L1
Other names/aliases FIP1
Rhe
hFip1
Species Homo sapiens
 Database cross references - FIP1L1
ExoCarta ExoCarta_81608
Vesiclepedia VP_81608
Entrez Gene 81608
HGNC 19124
MIM 607686
UniProt Q6UN15  
 FIP1L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FIP1L1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    mRNA cleavage and polyadenylation specificity factor complex GO:0005847 IBA
 Experiment description of studies that identified FIP1L1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FIP1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA5  
Affinity Capture-MS Homo sapiens
2 SNRPA 6626
Affinity Capture-MS Homo sapiens
3 LIG4 3981
Two-hybrid Homo sapiens
4 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 CRTAP 10491
Affinity Capture-MS Homo sapiens
7 PCF11 51585
Co-fractionation Homo sapiens
8 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
9 RIT1 6016
Negative Genetic Homo sapiens
10 PPIL4  
Affinity Capture-MS Homo sapiens
11 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
12 PRPF38A 84950
Affinity Capture-MS Homo sapiens
13 DHX8 1659
Proximity Label-MS Homo sapiens
14 RPS19 6223
Affinity Capture-MS Homo sapiens
15 PRMT6  
Two-hybrid Homo sapiens
16 KIF20A 10112
Affinity Capture-MS Homo sapiens
17 CSNK2A1 1457
Biochemical Activity Homo sapiens
18 CPSF4L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PRPF40A 55660
Affinity Capture-MS Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 CAPZB 832
Affinity Capture-MS Homo sapiens
22 DDX23 9416
Proximity Label-MS Homo sapiens
23 PPP1R10  
Affinity Capture-MS Homo sapiens
24 ATXN2L 11273
Affinity Capture-MS Homo sapiens
25 CPSF4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 COPS5 10987
Affinity Capture-MS Homo sapiens
27 PRC1 9055
Affinity Capture-MS Homo sapiens
28 CPSF7 79869
Affinity Capture-MS Homo sapiens
29 SRRM2 23524
Affinity Capture-MS Homo sapiens
30 SNRPC 6631
Affinity Capture-MS Homo sapiens
31 OBSL1 23363
Affinity Capture-MS Homo sapiens
32 TIAM1  
Affinity Capture-MS Homo sapiens
33 SGTA 6449
Two-hybrid Homo sapiens
34 ATG16L1 55054
Affinity Capture-MS Homo sapiens
35 MECP2 4204
Affinity Capture-MS Homo sapiens
36 MYCN  
Affinity Capture-MS Homo sapiens
37 CSNK1D 1453
Affinity Capture-MS Homo sapiens
38 ASF1A 25842
Proximity Label-MS Homo sapiens
39 KIF21A 55605
Affinity Capture-MS Homo sapiens
40 RBM14 10432
Affinity Capture-MS Homo sapiens
41 KIF14 9928
Affinity Capture-MS Homo sapiens
42 Arhgap1 228359
Affinity Capture-MS Mus musculus
43 CPEB1  
Affinity Capture-MS Homo sapiens
44 CHMP4C 92421
Affinity Capture-MS Homo sapiens
45 POP1 10940
Affinity Capture-MS Homo sapiens
46 CLK2 1196
Affinity Capture-MS Homo sapiens
47 SYMPK 8189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 P4HA1 5033
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 Anapc5 59008
Affinity Capture-MS Mus musculus
50 ARRDC3 57561
Affinity Capture-MS Homo sapiens
51 MEPCE 56257
Affinity Capture-MS Homo sapiens
52 CSTF2 1478
Affinity Capture-MS Homo sapiens
53 STAU1 6780
Affinity Capture-MS Homo sapiens
54 GOLGA2 2801
Two-hybrid Homo sapiens
55 Vav2  
Affinity Capture-MS Mus musculus
56 FOXL2  
Affinity Capture-MS Homo sapiens
57 CSTF3 1479
Affinity Capture-MS Homo sapiens
58 NTRK1 4914
Affinity Capture-MS Homo sapiens
59 P4HA2 8974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ARHGAP11A  
Affinity Capture-MS Homo sapiens
61 RAD18  
Affinity Capture-MS Homo sapiens
62 DTX2 113878
Proximity Label-MS Homo sapiens
63 NSRP1  
Affinity Capture-MS Homo sapiens
64 HIST1H1C 3006
Co-fractionation Homo sapiens
65 DHX40  
Proximity Label-MS Homo sapiens
66 GRAMD4 23151
Affinity Capture-MS Homo sapiens
67 CEBPA  
Protein-peptide Homo sapiens
68 WDR33 55339
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 KDF1  
Affinity Capture-MS Homo sapiens
70 WDR82 80335
Affinity Capture-MS Homo sapiens
71 OGT 8473
Reconstituted Complex Homo sapiens
72 FAM76B  
Affinity Capture-MS Homo sapiens
73 CPSF1 29894
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
74 PRPF4B 8899
Affinity Capture-MS Homo sapiens
75 CSTF1 1477
Affinity Capture-MS Homo sapiens
76 CDK9 1025
Affinity Capture-MS Homo sapiens
77 CSTF2T  
Affinity Capture-MS Homo sapiens
78 XPO1 7514
Affinity Capture-MS Homo sapiens
79 TSPYL5  
Affinity Capture-MS Homo sapiens
80 POLK  
Affinity Capture-MS Homo sapiens
81 CUL3 8452
Affinity Capture-MS Homo sapiens
82 DCAF13 25879
Affinity Capture-MS Homo sapiens
83 CTTN 2017
Affinity Capture-MS Homo sapiens
84 TOX4  
Affinity Capture-MS Homo sapiens
85 YY1 7528
Affinity Capture-MS Homo sapiens
86 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
87 SUZ12  
Affinity Capture-MS Homo sapiens
88 SART1 9092
Affinity Capture-MS Homo sapiens
89 P4HB 5034
Affinity Capture-MS Homo sapiens
90 AURKB 9212
Affinity Capture-MS Homo sapiens
91 ARHGAP29 9411
Affinity Capture-MS Homo sapiens
92 MFAP1  
Affinity Capture-MS Homo sapiens
93 MYC  
Affinity Capture-MS Homo sapiens
94 RPA3 6119
Proximity Label-MS Homo sapiens
95 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 SEC16A 9919
Affinity Capture-MS Homo sapiens
97 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
98 Stard13  
Affinity Capture-MS Mus musculus
99 TOP1 7150
Affinity Capture-MS Homo sapiens
100 SYDE2  
Affinity Capture-MS Homo sapiens
101 CUL7 9820
Affinity Capture-MS Homo sapiens
102 DDRGK1 65992
Affinity Capture-MS Homo sapiens
103 RNF2  
Affinity Capture-MS Homo sapiens
104 NUP153 9972
Co-fractionation Homo sapiens
105 PML 5371
Affinity Capture-MS Homo sapiens
106 PSPC1 55269
Affinity Capture-MS Homo sapiens
107 BRD3 8019
Affinity Capture-MS Homo sapiens
108 NAA10 8260
Two-hybrid Homo sapiens
109 CBX4  
Affinity Capture-MS Homo sapiens
110 RNF43  
Proximity Label-MS Homo sapiens
111 NUDT21 11051
Affinity Capture-MS Homo sapiens
112 LLGL2 3993
Affinity Capture-MS Homo sapiens
113 KIF2A 3796
Affinity Capture-MS Homo sapiens
114 C8orf33 65265
Affinity Capture-MS Homo sapiens
115 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
116 METTL17  
Affinity Capture-MS Homo sapiens
117 SIRT6  
Affinity Capture-MS Homo sapiens
118 PARP1 142
Proximity Label-MS Homo sapiens
119 CEP170P1  
Affinity Capture-MS Homo sapiens
120 CPSF6 11052
Affinity Capture-MS Homo sapiens
121 RBM25 58517
Affinity Capture-MS Homo sapiens
122 WWOX 51741
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
123 PDIA4 9601
Co-fractionation Homo sapiens
124 SF3B4 10262
Affinity Capture-MS Homo sapiens
125 NUFIP2 57532
Affinity Capture-MS Homo sapiens
126 MEN1 4221
Affinity Capture-MS Homo sapiens
127 PDHA1 5160
Affinity Capture-MS Homo sapiens
128 C1orf35  
Affinity Capture-MS Homo sapiens
129 LSS 4047
Affinity Capture-MS Homo sapiens
130 TAF2  
Affinity Capture-MS Homo sapiens
131 CPSF2 53981
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 MKI67  
Affinity Capture-MS Homo sapiens
133 ESR1  
Affinity Capture-MS Homo sapiens
134 UFL1 23376
Affinity Capture-MS Homo sapiens
135 WWP2 11060
Affinity Capture-MS Homo sapiens
136 LRPAP1 4043
Affinity Capture-MS Homo sapiens
137 EZH2  
Affinity Capture-MS Homo sapiens
138 EAF1  
Affinity Capture-MS Homo sapiens
139 CIT 11113
Affinity Capture-MS Homo sapiens
140 DDX42 11325
Affinity Capture-MS Homo sapiens
141 EIF5A 1984
Affinity Capture-MS Homo sapiens
142 SNW1 22938
Affinity Capture-MS Homo sapiens
143 KRAS 3845
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
144 C9orf72  
Affinity Capture-MS Homo sapiens
145 RC3H1 149041
Affinity Capture-MS Homo sapiens
146 ZMYND19  
Two-hybrid Homo sapiens
147 CCNT1  
Affinity Capture-MS Homo sapiens
148 VAV3 10451
Affinity Capture-MS Homo sapiens
149 PRMT1 3276
Affinity Capture-MS Homo sapiens
150 PRMT2  
Two-hybrid Homo sapiens
151 DDX56  
Affinity Capture-MS Homo sapiens
152 CPSF3 51692
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 EP300 2033
Affinity Capture-MS Homo sapiens
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