Gene description for TMF1
Gene name TATA element modulatory factor 1
Gene symbol TMF1
Other names/aliases ARA160
TMF
Species Homo sapiens
 Database cross references - TMF1
ExoCarta ExoCarta_7110
Vesiclepedia VP_7110
Entrez Gene 7110
HGNC 11870
MIM 601126
UniProt P82094  
 TMF1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TMF1
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IDA
    nuclear androgen receptor binding GO:0050681 IPI
Biological Process
    acrosome assembly GO:0001675 IEA
    positive regulation of cytokine production GO:0001819 IEA
    spermatid nucleus differentiation GO:0007289 IEA
    negative regulation of gene expression GO:0010629 IEA
    flagellated sperm motility GO:0030317 IEA
    androgen receptor signaling pathway GO:0030521 IDA
    luteinizing hormone secretion GO:0032275 IEA
    Leydig cell differentiation GO:0033327 IEA
    defense response to bacterium GO:0042742 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of proteasomal protein catabolic process GO:0061136 ISS
    epithelial cell apoptotic process GO:1904019 IEA
    negative regulation of epithelial cell apoptotic process GO:1904036 IEA
    positive regulation of testosterone secretion GO:2000845 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    nucleus GO:0005634 IEA
    endoplasmic reticulum GO:0005783 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TMF1 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 FAS 355
Proximity Label-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 PXMP2  
Proximity Label-MS Homo sapiens
5 PKN3 29941
Affinity Capture-MS Homo sapiens
6 TCP10  
Affinity Capture-MS Homo sapiens
7 CMTM5  
Two-hybrid Homo sapiens
8 USP7 7874
Affinity Capture-MS Homo sapiens
9 EBAG9 9166
Proximity Label-MS Homo sapiens
10 CBFA2T3  
Affinity Capture-MS Homo sapiens
11 BAG2 9532
Affinity Capture-MS Homo sapiens
12 GFI1B  
Two-hybrid Homo sapiens
13 TRIM31  
Affinity Capture-MS Homo sapiens
14 METTL7A 25840
Proximity Label-MS Homo sapiens
15 RAB5A 5868
Proximity Label-MS Homo sapiens
16 GJA1 2697
Proximity Label-MS Homo sapiens
17 NUP155 9631
Proximity Label-MS Homo sapiens
18 PPM1H  
Proximity Label-MS Homo sapiens
19 RAB9A 9367
Proximity Label-MS Homo sapiens
20 KAT2B  
Two-hybrid Homo sapiens
21 PDHA1 5160
Affinity Capture-MS Homo sapiens
22 BSPRY 54836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 HSD3B7 80270
Proximity Label-MS Homo sapiens
24 NR3C1 2908
Reconstituted Complex Homo sapiens
25 ARF1 375
Proximity Label-MS Homo sapiens
26 RB1CC1 9821
Affinity Capture-MS Homo sapiens
27 AP1M2 10053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 GORASP1 64689
Proximity Label-MS Homo sapiens
29 RAB4A 5867
Proximity Label-MS Homo sapiens
30 PFN1 5216
Proximity Label-MS Homo sapiens
31 ERGIC2 51290
Proximity Label-MS Homo sapiens
32 ITSN2 50618
Two-hybrid Homo sapiens
33 B3GAT1  
Proximity Label-MS Homo sapiens
34 RAB2A 5862
Proximity Label-MS Homo sapiens
35 MLLT4 4301
Proximity Label-MS Homo sapiens
36 FOXK2  
Affinity Capture-MS Homo sapiens
37 RAB7A 7879
Proximity Label-MS Homo sapiens
38 RAB11A 8766
Proximity Label-MS Homo sapiens
39 GOLGA1  
Proximity Label-MS Homo sapiens
40 KXD1 79036
Affinity Capture-MS Homo sapiens
41 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TCP10L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RAB3B 5865
Proximity Label-MS Homo sapiens
44 MOCS1  
Affinity Capture-MS Homo sapiens
45 RAB5C 5878
Proximity Label-MS Homo sapiens
46 AR 367
Two-hybrid Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
47 FER 2241
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
48 CAV1 857
Proximity Label-MS Homo sapiens
49 ELOVL5 60481
Proximity Label-MS Homo sapiens
50 STX6 10228
Proximity Label-MS Homo sapiens
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