Gene description for TFAP2C
Gene name transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Gene symbol TFAP2C
Other names/aliases AP2-GAMMA
ERF1
TFAP2G
hAP-2g
Species Homo sapiens
 Database cross references - TFAP2C
ExoCarta ExoCarta_7022
Entrez Gene 7022
HGNC 11744
MIM 601602
UniProt Q92754  
 TFAP2C identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TFAP2C
Molecular Function
    protein dimerization activity GO:0046983 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IEA
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    core promoter binding GO:0001047 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
Biological Process
    sebaceous gland development GO:0048733 IEA
    hair follicle development GO:0001942 IEA
    keratinocyte development GO:0003334 IEA
    regulation of gene expression, epigenetic GO:0040029 IMP
    cerebral cortex development GO:0021987 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    somatic stem cell maintenance GO:0035019 IEA
    regulation of epidermis development GO:0045682 IEA
    cell-cell signaling GO:0007267 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    trophectodermal cell differentiation GO:0001829 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    forebrain neuron fate commitment GO:0021877 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis GO:0060598 IEA
    germ-line stem cell maintenance GO:0030718 IEA
    epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA
    male gonad development GO:0008584 IEP
    regulation of cell proliferation GO:0042127 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TFAP2C in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TFAP2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CITED4  
Reconstituted Complex Homo sapiens
2 TP53  
Reconstituted Complex Homo sapiens
3 CITED2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which TFAP2C is involved
No pathways found





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