Gene description for TNS3
Gene name tensin 3
Gene symbol TNS3
Other names/aliases TEM6
TENS1
Species Homo sapiens
 Database cross references - TNS3
ExoCarta ExoCarta_64759
Entrez Gene 64759
HGNC 21616
MIM 606825
UniProt Q68CZ2  
 TNS3 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for TNS3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell migration GO:0016477 IEA
    positive regulation of cell proliferation GO:0008284 IEA
    lung alveolus development GO:0048286 IEA
Subcellular Localization
    focal adhesion GO:0005925 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified TNS3 in exosomes
1
Experiment ID 259
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 260
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TNS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TNS3 is involved
No pathways found





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