Gene description for RGS16
Gene name regulator of G-protein signaling 16
Gene symbol RGS16
Other names/aliases A28-RGS14
A28-RGS14P
RGS-R
Species Homo sapiens
 Database cross references - RGS16
ExoCarta ExoCarta_6004
Vesiclepedia VP_6004
Entrez Gene 6004
HGNC 9997
MIM 602514
UniProt O15492  
 RGS16 identified in exosomes derived from the following tissue/cell type
Urine 25452312    
 Gene ontology annotations for RGS16
Molecular Function
    GTPase activity GO:0003924 TAS
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 TAS
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 ISS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    visual perception GO:0007601 TAS
    regulation of G protein-coupled receptor signaling pathway GO:0008277 TAS
    negative regulation of signal transduction GO:0009968 IEA
    positive regulation of GTPase activity GO:0043547 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 ISS
 Experiment description of studies that identified RGS16 in exosomes
1
Experiment ID 238
MISEV standards
EM
Biophysical techniques
TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors "Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R."
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RGS16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Biochemical Activity Homo sapiens
2 GDE1 51573
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 GNA13 10672
Reconstituted Complex Homo sapiens
4 SRC 6714
Biochemical Activity Homo sapiens
5 GNAI2 2771
Reconstituted Complex Homo sapiens
6 ST14 6768
Two-hybrid Homo sapiens
7 GNAQ 2776
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 EGFR 1956
Affinity Capture-Western Homo sapiens
9 ZFP36  
Affinity Capture-RNA Homo sapiens
10 CSK 1445
Biochemical Activity Homo sapiens
11 GNAO1 2775
Reconstituted Complex Homo sapiens
12 GNAI3 2773
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 CREB3L2 64764
Two-hybrid Homo sapiens
14 GNAI1 2770
Biochemical Activity Homo sapiens
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