Gene description for RGS16
Gene name regulator of G-protein signaling 16
Gene symbol RGS16
Other names/aliases A28-RGS14
Species Homo sapiens
 Database cross references - RGS16
ExoCarta ExoCarta_6004
Entrez Gene 6004
HGNC 9997
MIM 602514
UniProt O15492  
 RGS16 identified in exosomes derived from the following tissue/cell type
Urine 25452312    
 Gene ontology annotations for RGS16
Molecular Function
    calmodulin binding GO:0005516 TAS
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    visual perception GO:0007601 TAS
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RGS16 in exosomes
Experiment ID 238
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R.
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RGS16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GDE1 51573
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 GNA13 10672
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 GNAI2 2771
Reconstituted Complex Homo sapiens
4 GNAQ 2776
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 EGFR 1956
Invivo Homo sapiens
6 GNAO1 2775
Reconstituted Complex Homo sapiens
7 GNAI3 2773
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 GNAI1 2770
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which RGS16 is involved
No pathways found

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