Gene description for SLC6A15
Gene name solute carrier family 6 (neutral amino acid transporter), member 15
Gene symbol SLC6A15
Other names/aliases NTT73
SBAT1
V7-3
hv7-3
Species Homo sapiens
 Database cross references - SLC6A15
ExoCarta ExoCarta_55117
Vesiclepedia VP_55117
Entrez Gene 55117
HGNC 13621
MIM 607971
UniProt Q9H2J7  
 SLC6A15 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC6A15
Molecular Function
    neutral L-amino acid:sodium symporter activity GO:0005295 IDA
    proline:sodium symporter activity GO:0005298 IBA
    neurotransmitter transmembrane transporter activity GO:0005326 NAS
    protein binding GO:0005515 IPI
    amino acid transmembrane transporter activity GO:0015171 TAS
    branched-chain amino acid:sodium symporter activity GO:0015657 IDA
Biological Process
    amino acid transmembrane transport GO:0003333 IEA
    neurotransmitter transport GO:0006836 NAS
    amino acid transport GO:0006865 TAS
    neutral amino acid transport GO:0015804 IDA
    L-leucine transport GO:0015820 IBA
    L-leucine transport GO:0015820 ISS
    proline transport GO:0015824 ISS
    sodium ion transmembrane transport GO:0035725 IBA
    carboxylic acid transmembrane transport GO:1905039 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified SLC6A15 in exosomes
1
Experiment ID 257
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC6A15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GJD3  
Proximity Label-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 OCLN 100506658
Proximity Label-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 LAMP3  
Proximity Label-MS Homo sapiens
6 ATG9A 79065
Proximity Label-MS Homo sapiens
7 GJA1 2697
Proximity Label-MS Homo sapiens
8 ARL6IP5 10550
Affinity Capture-MS Homo sapiens
9 PARD3 56288
Proximity Label-MS Homo sapiens
10 HSD17B11 51170
Proximity Label-MS Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 STX4 6810
Proximity Label-MS Homo sapiens
13 PIGU 128869
Affinity Capture-MS Homo sapiens
14 CENPA  
Proximity Label-MS Homo sapiens
15 PTRH2 51651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 B3GAT1  
Proximity Label-MS Homo sapiens
17 MLLT4 4301
Proximity Label-MS Homo sapiens
18 TMPPE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RAB3B 5865
Proximity Label-MS Homo sapiens
20 STX7 8417
Affinity Capture-MS Homo sapiens
21 SSR1 6745
Proximity Label-MS Homo sapiens
22 AGPAT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RPN2 6185
Proximity Label-MS Homo sapiens
24 STX6 10228
Proximity Label-MS Homo sapiens
25 TMTC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KIF2C 11004
Affinity Capture-MS Homo sapiens
27 RAB35 11021
Proximity Label-MS Homo sapiens
28 EBAG9 9166
Proximity Label-MS Homo sapiens
29 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MARCKS 4082
Proximity Label-MS Homo sapiens
31 LAMTOR1 55004
Proximity Label-MS Homo sapiens
32 NCOA1  
Affinity Capture-MS Homo sapiens
33 LMAN1 3998
Proximity Label-MS Homo sapiens
34 RAB4A 5867
Proximity Label-MS Homo sapiens
35 PXMP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NOMO1 23420
Affinity Capture-MS Homo sapiens
37 ATP8B2 57198
Affinity Capture-MS Homo sapiens
38 RAB14 51552
Affinity Capture-MS Homo sapiens
39 CXADR 1525
Proximity Label-MS Homo sapiens
40 TMEM55B 90809
Affinity Capture-MS Homo sapiens
41 LYN 4067
Proximity Label-MS Homo sapiens
42 MCAM 4162
Proximity Label-MS Homo sapiens
43 TLCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 DNAJC5 80331
Proximity Label-MS Homo sapiens
45 DIRAS3  
Proximity Label-MS Homo sapiens
46 RPN1 6184
Proximity Label-MS Homo sapiens
47 TEX29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ELOVL5 60481
Proximity Label-MS Homo sapiens
49 SEC61B 10952
Proximity Label-MS Homo sapiens
50 TEX2 55852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SPPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 HSD3B7 80270
Proximity Label-MS Homo sapiens
53 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CANX 821
Affinity Capture-MS Homo sapiens
55 RAB5A 5868
Proximity Label-MS Homo sapiens
56 EPB41L4A 64097
Proximity Label-MS Homo sapiens
57 LAMP1 3916
Proximity Label-MS Homo sapiens
58 ATG12  
Proximity Label-MS Homo sapiens
59 BCAP31 10134
Proximity Label-MS Homo sapiens
60 VAMP3 9341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ARF6 382
Proximity Label-MS Homo sapiens
62 ALG8  
Affinity Capture-MS Homo sapiens
63 KLHL36  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MFAP1  
Affinity Capture-MS Homo sapiens
65 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ATP2A1 487
Proximity Label-MS Homo sapiens
67 RAB9A 9367
Proximity Label-MS Homo sapiens
68 GOLGA1  
Proximity Label-MS Homo sapiens
69 RHOB 388
Proximity Label-MS Homo sapiens
70 FLOT1 10211
Proximity Label-MS Homo sapiens
71 ANKFY1 51479
Proximity Label-MS Homo sapiens
72 GPR89A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 TP53 7157
Affinity Capture-MS Homo sapiens
74 AGPAT9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PPM1H  
Proximity Label-MS Homo sapiens
76 EZR 7430
Proximity Label-MS Homo sapiens
77 COX8A  
Proximity Label-MS Homo sapiens
78 EBP  
Affinity Capture-MS Homo sapiens
79 AGPAT3 56894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ERGIC1 57222
Proximity Label-MS Homo sapiens
81 C11orf52 91894
Proximity Label-MS Homo sapiens
82 RAB1A 5861
Affinity Capture-MS Homo sapiens
83 ACSL4 2182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 HACD2 201562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ERGIC2 51290
Proximity Label-MS Homo sapiens
86 RAB2A 5862
Proximity Label-MS Homo sapiens
87 SEC62 7095
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 GOLGA5 9950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 RAB7A 7879
Proximity Label-MS Homo sapiens
90 RAB11A 8766
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 EPHA2 1969
Proximity Label-MS Homo sapiens
92 KRAS 3845
Proximity Label-MS Homo sapiens
93 RAB5C 5878
Proximity Label-MS Homo sapiens
94 CKAP4 10970
Proximity Label-MS Homo sapiens
95 CAV1 857
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 LNX1  
Two-hybrid Homo sapiens
97 CUL4A 8451
Affinity Capture-MS Homo sapiens
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