Gene description for SLC6A15
Gene name solute carrier family 6 (neutral amino acid transporter), member 15
Gene symbol SLC6A15
Other names/aliases NTT73
SBAT1
V7-3
hv7-3
Species Homo sapiens
 Database cross references - SLC6A15
ExoCarta ExoCarta_55117
Vesiclepedia VP_55117
Entrez Gene 55117
HGNC 13621
MIM 607971
UniProt Q9H2J7  
 SLC6A15 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC6A15
Molecular Function
    neurotransmitter transporter activity GO:0005326 NAS
    neurotransmitter:sodium symporter activity GO:0005328 IEA
    proline:sodium symporter activity GO:0005298 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    leucine transport GO:0015820 ISS
    ion transport GO:0006811 TAS
    sodium ion transport GO:0006814 IEA
    neurotransmitter transport GO:0006836 NAS
    proline transmembrane transport GO:0035524 IEA
    neutral amino acid transport GO:0015804 IDA
    amino acid transport GO:0006865 TAS
    proline transport GO:0015824 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 NAS
    integral component of plasma membrane GO:0005887 IEA
 Experiment description of studies that identified SLC6A15 in exosomes
1
Experiment ID 257
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|FLOT1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC6A15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC6A15 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane TAS Reactome
Na+/Cl- dependent neurotransmitter transporters TAS Reactome





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