Gene description for GPRIN1
Gene name G protein regulated inducer of neurite outgrowth 1
Gene symbol GPRIN1
Other names/aliases GRIN1
Species Homo sapiens
 Database cross references - GPRIN1
ExoCarta ExoCarta_114787
Vesiclepedia VP_114787
Entrez Gene 114787
HGNC 24835
MIM 611239
UniProt Q7Z2K8  
 GPRIN1 identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for GPRIN1
Molecular Function
    protein binding GO:0005515 IPI
    phosphoprotein binding GO:0051219 IEA
Biological Process
    neuron projection development GO:0031175 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    growth cone GO:0030426 IEA
 Experiment description of studies that identified GPRIN1 in exosomes
1
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GPRIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEA8  
Affinity Capture-MS Homo sapiens
2 YEATS4  
Affinity Capture-MS Homo sapiens
3 HNRNPD 3184
Affinity Capture-MS Homo sapiens
4 RAB35 11021
Proximity Label-MS Homo sapiens
5 NTRK1 4914
Affinity Capture-MS Homo sapiens
6 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
7 OCLN 100506658
Proximity Label-MS Homo sapiens
8 MARCKS 4082
Proximity Label-MS Homo sapiens
9 LAMTOR1 55004
Proximity Label-MS Homo sapiens
10 PTPRG 5793
Proximity Label-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
12 VTN 7448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EEF2 1938
Cross-Linking-MS (XL-MS) Homo sapiens
14 EZR 7430
Proximity Label-MS Homo sapiens
15 CYP2S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LCK 3932
Proximity Label-MS Homo sapiens
17 TUBB4B 10383
Affinity Capture-MS Homo sapiens
18 ARF6 382
Proximity Label-MS Homo sapiens
19 CXADR 1525
Proximity Label-MS Homo sapiens
20 ZNF281  
Affinity Capture-MS Homo sapiens
21 STX4 6810
Proximity Label-MS Homo sapiens
22 C11orf52 91894
Proximity Label-MS Homo sapiens
23 LYN 4067
Proximity Label-MS Homo sapiens
24 MCAM 4162
Proximity Label-MS Homo sapiens
25 RELL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GJB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 KCNE3  
Affinity Capture-MS Homo sapiens
28 DNAJC5 80331
Proximity Label-MS Homo sapiens
29 CDH1 999
Proximity Label-MS Homo sapiens
30 S1PR1 1901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RAB7A 7879
Proximity Label-MS Homo sapiens
32 EPHA2 1969
Proximity Label-MS Homo sapiens
33 ACTB 60
Proximity Label-MS Homo sapiens
34 KRAS 3845
Proximity Label-MS Homo sapiens
35 RHOB 388
Proximity Label-MS Homo sapiens
36 STAMBPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CAV1 857
Proximity Label-MS Homo sapiens
39 CTDSPL 10217
Proximity Label-MS Homo sapiens
40 FLOT1 10211
Proximity Label-MS Homo sapiens
41 STX6 10228
Proximity Label-MS Homo sapiens
42 CERS2 29956
Affinity Capture-MS Homo sapiens
43 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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