Gene description for ZGRF1
Gene name zinc finger, GRF-type containing 1
Gene symbol ZGRF1
Other names/aliases C4orf21
Species Homo sapiens
 Database cross references - ZGRF1
ExoCarta ExoCarta_55345
Vesiclepedia VP_55345
Entrez Gene 55345
HGNC 25654
UniProt Q86YA3  
 ZGRF1 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ZGRF1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    zinc ion binding GO:0008270 IEA
    hydrolase activity GO:0016787 IEA
    isomerase activity GO:0016853 IEA
    5'-3' DNA helicase activity GO:0043139 IDA
Biological Process
    recombinational repair GO:0000725 IDA
    recombinational repair GO:0000725 IMP
    double-strand break repair GO:0006302 IBA
    DNA duplex unwinding GO:0032508 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    site of double-strand break GO:0035861 IBA
 Experiment description of studies that identified ZGRF1 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZGRF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 HSPA4 3308
Affinity Capture-MS Homo sapiens
3 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
4 KIF11 3832
Affinity Capture-MS Homo sapiens
5 PTGES3 10728
Affinity Capture-MS Homo sapiens
6 PRKCSH 5589
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
7 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
8 VPS18 57617
Affinity Capture-MS Homo sapiens
9 DHX36 170506
Cross-Linking-MS (XL-MS) Homo sapiens
10 PIP 5304
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZGRF1 is involved
No pathways found





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