Gene description for ELMO2
Gene name engulfment and cell motility 2
Gene symbol ELMO2
Other names/aliases CED-12
CED12
ELMO-2
Species Homo sapiens
 Database cross references - ELMO2
ExoCarta ExoCarta_63916
Entrez Gene 63916
HGNC 17233
MIM 606421
UniProt Q96JJ3  
 ELMO2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ELMO2
Molecular Function
    SH3 domain binding GO:0017124 IEA
    protein binding GO:0005515 IPI
    receptor tyrosine kinase binding GO:0030971 IPI
Biological Process
    cytoskeleton organization GO:0007010 IEA
    cell chemotaxis GO:0060326 IMP
    innate immune response GO:0045087 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    apoptotic process GO:0006915 IEA
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ELMO2 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ELMO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DOCK1 1793
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ELMO2 is involved
PathwayEvidenceSource
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome





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